M-CONE AND L-CONE IN MACAQUE FOVEA CONNECT TO MIDGET GANGLION-CELLS BY DIFFERENT NUMBERS OF EXCITATORY SYNAPSES
M-CONE AND L-CONE IN MACAQUE FOVEA CONNECT TO MIDGET GANGLION-CELLS BY DIFFERENT NUMBERS OF EXCITATORY SYNAPSES
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DOI：
10.1038/371070a0
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发表时间：
1994-09-01
期刊：
影响因子：
64.8
通讯作者：
STERLING, P
中科院分区：
文献类型：
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作者：
CALKINS, DJ;SCHEIN, SJ;STERLING, P
视觉敏锐度取决于中心凹视锥马赛克(1-3)设置的细粒度神经图像。为了保存这种空间细节，视锥细胞通过非发散的路径进行传递：视锥-->；侏儒双极细胞-侏儒神经节细胞。必须沿每条路径建立足够的增益；必须最大限度地减少路径之间的串扰和变化源。这些要求提出了关于突触连接的基本问题：(1)从两极到神经节细胞的突触中有多少传递锥体信号，相邻路径之间的串扰程度如何；(2)这些连接在马赛克上的复制有多准确；以及(3)中(M)和长(L)波长敏感锥体的侏儒电路是否相同。我们在这里报道了侏儒神经节细胞无串扰地收集28+/-14或47+/-3个侏儒双极突触。根据这一差异可以定义两种锥体类型：数量大致相等，随机分布在类似类型的小簇中，它们可能是M和L。
VISUAL acuity depends on the fine-grained neural image set by the foveal cone mosaic(1-3). To preserve this spatial detail, cones transmit through non-divergent pathways: cone-->midget bipolar cell-->midget ganglion cell. Adequate gain must be established along each pathway; crosstalk and sources of variation between pathways must be minimized. These requirements raise fundamental questions regarding the synaptic connections: (1) how many synapses from bipolar to ganglion cell transmit a cone signal and with what degree of crosstalk between adjacent pathways; (2) how accurately these connections are reproduced across the mosaic; and (3) whether the midget circuits for middle (M) and long (L) wavelength sensitive cones are the same. We report here that the midget ganglion cell collects without crosstalk either 28 +/- 14 or 47 +/- 3 midget bipolar synapses. Two cone types are defined by this difference; being about equal in number and distributing randomly in small clusters of like type, they are probably M and L.