A Critical Role for Neocortical Processing of Threat Memory
A Critical Role for Neocortical Processing of Threat Memory
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DOI：
10.1016/j.neuron.2019.09.025
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发表时间：
2019-12-18
期刊：
影响因子：
16.2
通讯作者：
Letzkus, Johannes J.
中科院分区：
文献类型：
--
作者：
Dalmay, Tamas;Abs, Elisabeth;Letzkus, Johannes J.
与威胁相关的线索记忆对于生存至关重要，也是阐明感官信息如何通过学习与适应性行为联系起来的领先模型。尽管介导听觉威胁记忆的全脑回路已被深入研究，但仍不清楚听觉皮层是否参与其中。在这里，我们在确定的皮质区域和输出通路中使用光遗传学活动操作、病毒追踪、通路特异性体内2光子钙成像以及群体可塑性的计算分析来揭示听觉皮层是选择性地调节复杂刺激所必需的，而相邻的时间关联皮层控制着所有形式的听觉威胁记忆。更多的颞区对记忆有更强的影响，更多的神经元投射到外侧杏仁核，外侧杏仁核通过平衡形式的群体可塑性控制对复杂刺激的记忆，选择性地支持对重要感觉刺激的辨别。因此，新皮质处理在提示威胁记忆中起着至关重要的作用。
Memory of cues associated with threat is critical for survival and a leading model for elucidating how sensory information is linked to adaptive behavior by learning. Although the brain-wide circuits mediating auditory threat memory have been intensely investigated, it remains unclear whether the auditory cortex is critically involved. Here we use optogenetic activity manipulations in defined cortical areas and output pathways, viral tracing, pathway-specific in vivo 2-photon calcium imaging, and computational analyses of population plasticity to reveal that the auditory cortex is selectively required for conditioning to complex stimuli, whereas the adjacent temporal association cortex controls all forms of auditory threat memory. More temporal areas have a stronger effect on memory and more neurons projecting to the lateral amygdala, which control memory to complex stimuli through a balanced form of population plasticity that selectively supports discrimination of significant sensory stimuli. Thus, neocortical processing plays a critical role in cued threat memory.