Human papillomavirus genotype prevalence in invasive penile cancers from a registry-based United States population.
Human papillomavirus genotype prevalence in invasive penile cancers from a registry-based United States population.
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DOI：
10.3389/fonc.2014.00009
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发表时间：
2014
影响因子：
4.7
通讯作者：
HPV Typing of Cancer Workgroup
中科院分区：
文献类型：
--
作者：
Hernandez BY;Goodman MT;Unger ER;Steinau M;Powers A;Lynch CF;Cozen W;Saber MS;Peters ES;Wilkinson EJ;Copeland G;Hopenhayn C;Huang Y;Watson M;Altekruse SF;Lyu C;Saraiya M;HPV Typing of Cancer Workgroup
背景：据估计，人乳头瘤病毒（HPV）在全球40-50%的阴茎癌中起病因作用。美国阴茎癌病例中HPV患病率的估计是有限的。研究方法：在1998-2005年在美国7个癌症登记处的集水区诊断的79名浸润性阴茎癌患者的肿瘤组织中评估了HPV DNA。使用基于PCR的线性阵列和INNO-LiPA检测对HPV进行基因分型，并通过人口统计学、临床和病理特征以及生存率进行比较。还通过独立病理学审查获得组织学分类。结果：79例浸润性阴茎癌中有50例（63%）存在HPV DNA。共检测到16种病毒基因型。HPV 16型占所有病例的46%（36/79）（HPV阳性病例的72%），是最常见的基因型，其次是HPV 18，33和45，各占所有病例的5%。在18%的病毒阳性病例中检测到多种基因型。HPV感染率在年龄、种族/民族、地理区域的人口规模、癌症分期、组织学、分级、阴茎亚部位或既往癌症史方面没有显著差异。近年来诊断的阴茎病例更有可能是HPV阳性。总生存期没有显着差异HPV状态。结论：在我们的研究人群中HPV的相对较高的患病率提供了有限的证据，证明与世界其他地区相比，美国的感染在阴茎癌发生中的作用更为突出，并且可能越来越大。
Background: Human papillomavirus (HPV) is estimated to play an etiologic role in 40–50% of penile cancers worldwide. Estimates of HPV prevalence in U.S. penile cancer cases are limited. Methods: HPV DNA was evaluated in tumor tissue from 79 invasive penile cancer patients diagnosed in 1998–2005 within the catchment areas of seven U.S. cancer registries. HPV was genotyped using PCR-based Linear Array and INNO-LiPA assays and compared by demographic, clinical, and pathologic characteristics and survival. Histological classification was also obtained by independent pathology review. Results: HPV DNA was present in 50 of 79 (63%) of invasive penile cancer cases. Sixteen viral genotypes were detected. HPV 16, found in 46% (36/79) of all cases (72% of HPV-positive cases) was the most prevalent genotype followed equally by HPV 18, 33, and 45, each of which comprised 5% of all cases. Multiple genotypes were detected in 18% of viral positive cases. HPV prevalence did not significantly vary by age, race/ethnicity, population size of geographic region, cancer stage, histology, grade, penile subsite, or prior cancer history. Penile cases diagnosed in more recent years were more likely to be HPV-positive. Overall survival did not significantly vary by HPV status. Conclusion: The relatively high prevalence of HPV in our study population provides limited evidence of a more prominent and, possibly, increasing role of infection in penile carcinogenesis in the U.S. compared to other parts of the world.