The pathogenesis of keratoconus
The pathogenesis of keratoconus
复制标题
DOI：
10.1038/eye.2013.278
复制
发表时间：
2014-02-01
期刊：
影响因子：
3.9
通讯作者：
Tuft, S. J.
中科院分区：
文献类型：
--
作者：
Davidson, A. E.;Hayes, S.;Tuft, S. J.
圆锥角膜（KC）是一种常见的退行性疾病，通常会导致视力丧失，通常在成年早期发病。这是发达国家角膜移植术最常见的原因。病因和潜在的病理机制尚不清楚，但环境和遗传因素都被认为有助于疾病的发展。已经采用了各种策略来解决我们对这种复杂疾病的理解中的差距，期望随着时间的推移，将开发出更复杂的治疗方法。在这篇综述中，我们总结了我们目前的知识的病因学和危险因素与KC。
Keratoconus (KC) is a common degenerative condition that frequently results in visual loss with an onset typically in early adulthood. It is the single most common reason for keratoplasty in the developed world. The cause and underlying pathological mechanism are unknown, but both environmental and genetic factors are thought to contribute to the development of the disease. Various strategies have been employed to address the gap in our understanding of this complex disease, with the expectation that over time more sophisticated therapies will be developed. In this review we summarise our current knowledge of the aetiology and risk factors associated with KC.