The role of Langerhans cells in allergic contact hypersensitivity. A review of findings in man and guinea pigs.
The role of Langerhans cells in allergic contact hypersensitivity. A review of findings in man and guinea pigs.
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朗格汉斯细胞在过敏性接触超敏反应中的作用。
DOI：
10.1111/1523-1747.ep12482139
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发表时间：
1976
期刊：
影响因子：
--
通讯作者：
S. Rosenthal
中科院分区：
文献类型：
--
作者：
I. Silberberg;R. Baer;S. Rosenthal
已对支持朗格汉斯细胞在接触性过敏性超敏反应中发挥作用的证据进行了综述。这包括单核细胞与朗格汉斯细胞的沉积以及对各种接触性过敏原特异性激发部位的一些朗格汉斯细胞的损伤。主动致敏的患者和豚鼠以及被动致敏的豚鼠中均发生这种沉积。此外，在被动致敏的豚鼠中，朗格汉斯细胞在真皮血管中循环，类似于血管内皮细胞，并且在用接触性变应原激发后在真皮中大量增加。这些观察结果，以及现有的知识，即朗格汉斯细胞出现在淋巴结和胸腺，表明这些细胞可能不仅参与接触过敏反应，而且还参与其他免疫反应，特别是在皮肤中的细胞介导的反应。
Evidence in favor of a role for Langerhans cells in contact allergic hypersensitivity reactions has been reviewed. This includes mononuclear cell to Langerhans cell apposition and damage to some Langerhans cells at sites of specific challenge to a variety of contact allergens. Such apposition occurs in actively sensitized patients and guinea pigs and in passively sensitized guinea pigs. In addition, in passively sensitized guinea pigs Langerhans cells circulate in dermal vessels resembling lymphatics and are much increased in the dermis after challenge with the contact allergen. These observations, together with the existing knowledge that Langerhans cells occur in the lymph nodes and thymus, suggest that these cells may be involved not only in contact allergic reactions but also in other immunologic reactions, particularly in cell-mediated reactions in the skin.