Prevalence of cytomegalovirus antibody in hemophiliacs and homosexuals infected with human immunodeficiency virus type 1.
Prevalence of cytomegalovirus antibody in hemophiliacs and homosexuals infected with human immunodeficiency virus type 1.
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感染人类免疫缺陷病毒 1 型的血友病患者和同性恋者中巨细胞病毒抗体的患病率。
DOI：
10.1046/j.1537-2995.1988.28288179029.x
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发表时间：
1988
期刊：
影响因子：
2.9
通讯作者：
BalfourJr,HH
中科院分区：
文献类型：
--
作者：
Jackson,JB;Erice,A;Englund,JA;Edson,JR;BalfourJr,HH
我们确定了非同性恋血友病患者和感染人类免疫缺陷病毒1型（HIV-1）的同性恋男性血清中巨细胞病毒（CMV）抗体的患病率。乳胶凝集法CMV抗体检测显示，58名HIV-1感染的血友病患者中有33名（57%）抗体阳性，而54名HIV-1感染的无症状非血友病同性恋者中有54名（100%）抗体阳性（p <0.001）。15例有症状的HIV-1感染血友病患者中有9例（60%）为CMV抗体阳性。我们还测试了22名接受非热处理因子浓缩物的HIV-1抗体阴性血友病患者。这22例患者中有14例（64%）为CMV抗体阳性，而HIV-1抗体阳性血友病患者为57%。我们得出结论：1）因子浓缩物传播HIV-1和CMV之间几乎没有相关性，2）CMV抗体的存在似乎与血友病患者HIV-1感染的临床分期无关，和3）如果不提供CMV血清阴性血液制品，可能会有大量CMV抗体阴性血友病患者的HIV-1感染存在原发感染和继发疾病的风险。未来的输血
We determined the prevalence of antibody to cytomegalovirus (CMV) in the sera of non‐homosexual hemophilia patients and homosexual men infected with the human immunodeficiency virus type 1 (HIV‐1). CMV antibody testing by latex agglutination revealed 33 of 58 HIV‐1 infected hemophiliacs (57%) were antibody‐positive compared with 54 of 54 HIV‐1 infected asymptomatic non‐hemophiliac homosexuals (100%) (p less than .001). Nine of 15 hemophiliacs (60%) with symptomatic HIV‐1 infection were CMV antibody‐positive. We also tested 22 HIV‐1 antibody‐ negative hemophiliacs who had received non‐heat treated factor concentrates. 14 of these 22 (64%) were CMV antibody‐positive compared with 57% of HIV‐1 antibody‐positive hemophiliacs. We conclude 1) there is little correlation between transmission of HIV‐1 and CMV by factor concentrates, 2) the presence of CMV antibody does not appear to be associated with clinical stage of HIV‐1 infection in hemophiliacs, and 3) there may be a significant number of CMV antibody‐negative hemophiliacs with HIV‐1 infection at risk for primary infection and subsequent disease if CMV seronegative blood products are not provided for future transfusions.