Apoptosis (programmed cell death) and its signals - A review
Apoptosis (programmed cell death) and its signals - A review
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DOI：
10.1590/1519-6984.228437
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发表时间：
2021-12-01
影响因子：
--
通讯作者：
Obeng, E.
中科院分区：
文献类型：
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作者：
Obeng, E.
细胞凋亡是细胞死亡的一个顺序，有规律地发生，以确保细胞形成速率和细胞死亡速率之间的稳态平衡。然而，这种平衡功能的错位可导致细胞生长/增殖异常或自身免疫性疾病等。因此，细胞凋亡被认为是至关重要的，从胚胎的发育到生物体的生长，有助于组织的更新，也有助于消除炎症细胞。本文综述了近年来有关细胞凋亡的研究进展，包括细胞凋亡的机制、细胞凋亡的功能和抑制因素，以及细胞凋亡的功能障碍是如何导致一些癌症相关病例的。
Apoptosis is a sequential order of cell death occurring regularly to ensure a homeostatic balance between the rate of cell formation and cell death. However, a misplaced of this balancing function can contribute to an abnormal cell growth / proliferation or autoimmune disorders etc. Apoptosis is therefore said to be crucial from the point of development of an embryo throughout the growth of an organism contributing to the renewal of tissues and also the getting rid of inflammatory cells. This review seeks to elaborate on the recent overview of the mechanism involved in apoptosis, some element and signal contributing to its function and inhibition together with how their malfunction contribute to a number of cancer related cases.