Respiratory Syncytial Virus Provides Protection against a Subsequent Influenza A Virus Infection.
Respiratory Syncytial Virus Provides Protection against a Subsequent Influenza A Virus Infection.
复制标题
DOI：
10.4049/jimmunol.2000751
复制
发表时间：
2022-02-01
期刊：
影响因子：
--
通讯作者：
Varga SM
中科院分区：
文献类型：
--
作者：
Hartwig SM;Miller AM;Varga SM
呼吸道感染是发病和死亡的主要原因。在筛选呼吸道病毒存在的个体子集中，通常会观察到多种异源病毒感染的存在。然而，重叠感染对疾病严重程度和宿主免疫反应的影响尚不清楚。呼吸道合胞病毒（RSV）和甲型流感病毒（IAV）是住院患者中最常见的两种呼吸道感染，特别是在幼儿和老年人群中。在这里，我们研究了 BALB/c 小鼠感染 RSV 和 IAV 的顺序如何影响疾病的严重程度。与单独感染 IAV 相比，感染 IAV 之前感染 RSV 与体重减轻减少和生存率增加相关。相反，与单独的 IAV 感染相比，RSV 感染之前的 IAV 感染与相似的发病率和死亡率相关。我们的结果表明，病毒感染的获得顺序对疾病严重程度和宿主免疫反应的结果起着至关重要的作用。
Respiratory infections are a leading cause of morbidity and mortality. The presence of multiple heterologous virus infections is routinely observed in a subset of individuals screened for the presence of respiratory viruses. However, the impact overlapping infections has on disease severity and the host immune response is not well understood. Respiratory syncytial virus (RSV) and influenza A virus (IAV) are two of the most common respiratory infections observed in hospitalized patients, particularly in the very young and aged populations. Here we examined how the order in which BALB/c mice were infected with both RSV and IAV impacts disease severity. RSV infection prior to an IAV infection was associated with decreased weight loss and increased survival as compared to IAV infection alone. In contrast, IAV infection prior to an RSV infection was associated with similar morbidity and mortality as compared to an IAV infection alone. Our results suggest that the order in which viral infections are acquired plays a critical role in the outcome of disease severity and the host immune response.
登录
查看更多内容
影响因子：
3.7
作者：
Do AH;van Doorn HR;Nghiem MN;Bryant JE;Hoang TH;Do QH;Van TL;Tran TT;Wills B;Nguyen VC;Vo MH;Vo CK;Nguyen MD;Farrar J;Tran TH;de Jong MD
通讯作者：
de Jong MD
在B淋巴细胞缺陷小鼠中对致命流感病毒感染的抗性和恢复。
影响因子：
15.3
作者：
Graham, M B;Braciale, T J
通讯作者：
Braciale, T J
DOI：
10.4049/jimmunol.1000423
发表时间：
2010-08-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Fulton RB;Meyerholz DK;Varga SM
通讯作者：
Varga SM
DOI：
10.4049/jimmunol.181.10.6692
发表时间：
2008-11-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Castilow EM;Legge KL;Varga SM
通讯作者：
Varga SM
影响因子：
9.4
作者：
Hu, AZ;Colella, M;Cheng, SM
通讯作者：
Cheng, SM