Extinction-induced spatial dispersion in the radial arm maze: arrest by ethanol.

Extinction-induced spatial dispersion in the radial arm maze: arrest by ethanol.
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径向臂迷宫中灭绝引起的空间分散:乙醇逮捕。

DOI:
10.1037//0735-7044.98.6.979
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发表时间:
1984
影响因子:
1.9
通讯作者:
Devenport,LD
Devenport,LD
中科院分区:
医学4区
文献类型:
--
作者:
Devenport,LD

文献摘要

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通过制定允许行为偏离训练常规的规定,调查了应对灭绝的适应性变化。在一个8臂的径向迷宫中,4只手臂的诱饵越来越限制了32只雄性Sprague-Dawley大鼠对这些手臂的运动:在灭绝过程中,无诱饵的手臂为行为提供了一个新的方向。在撤销奖励后,立即积极扩大视察地点,并定期对以前未获得奖励的武器进行抽样。这是灭绝的后果之一;另一个是武器进入的总体速度下降,无论武器以前是否被引诱。乙醇(1.5或2.0 g/kg)消除了空间分散伴随nonreward,但不影响整体反应性的下降。它的结论是,乙醇的删除引起的空间变异性可以解释其损害逆转和其他类型的任务,需要从旧的行为模式的转变。(23参考)(PsycINFO数据库记录(c)2016阿帕,保留所有权利)
Investigated adaptive changes in response to extinction by making provisions that permitted behavior to shift away from trained routine. The baiting of 4 arms in an 8-arm radial maze increasingly restricted movements by 32 male Sprague-Dawley rats to those arms: The unbaited arms afforded a new direction for behavior to take during extinction. Withdrawal of reward was followed by an immediate and active expansion of visited sites, and previously unrewarded arms were regularly sampled. This was one consequence of extinction; the other was the decline in overall rate of arm entry, whether arms were previously baited or not. Ethanol (1.5 or 2.0 g/kg) eliminated the spatial dispersions attendant on nonreward but did not affect the decline in overall responsiveness. It is concluded that ethanol's deletion of extinction-induced spatial variability may account for its impairment on reversal and other kinds of tasks that require a shift away from old patterns of behavior.(23 ref)(PsycINFO Database Record (c) 2016 APA, all rights reserved)