Plasma metabolites associated with cognitive function across race/ethnicities affirming the importance of healthy nutrition.
Plasma metabolites associated with cognitive function across race/ethnicities affirming the importance of healthy nutrition.
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DOI：
10.1002/alz.12786
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发表时间：
2023-04
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我们研究了先前确定的代谢物的复制和泛化，这些代谢物可能与多个种族/民族的整体认知功能相关，并评估了饮食对这些关联的贡献。我们测试了来自社区健康研究/拉丁裔研究（HCHS/SOL）的美国西班牙裔/拉丁裔成年人（n= 2，222）以及来自社区动脉粥样硬化风险（ARIC）研究的欧洲（n= 1，365）和非洲裔（n=478）美国人的代谢-认知功能关联。我们应用孟德尔随机化（MR）分析来评估代谢物和认知功能之间以及地中海饮食和认知功能之间的因果关系。在所有研究中，6种代谢物始终与较低的整体认知功能相关。其中，四个与糖有关（例如，核糖醇）。MR分析为核糖醇对认知功能的潜在因果效应和认知表现对饮食的双向效应提供了弱证据。在不同人种/种族的研究中，几种饮食相关代谢物与整体认知功能相关。
We studied the replication and generalization of previously identified metabolites potentially associated with global cognitive function in multiple race/ethnicities and assessed the contribution of diet to these associations. We tested metabolite-cognitive function associations in the U.S.A. Hispanic/Latino adults (n= 2,222) from the Community Health Study/Study of Latinos (HCHS/SOL) and in European (n=1,365) and African (n=478) Americans from the Atherosclerosis Risk In Communities (ARIC) Study. We applied Mendelian Randomization (MR) analyses to assess causal associations between the metabolites and cognitive function and between Mediterranean diet and cognitive function. Six metabolites were consistently associated with lower global cognitive function across all studies. Of these, four were sugar-related (e.g., ribitol). MR analyses provided weak evidence for a potential causal effect of ribitol on cognitive function and bi-directional effects of cognitive performance on diet. Several diet-related metabolites were associated with global cognitive function across studies with different race/ethnicities.