Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia
Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia
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DOI：
10.1016/s1074-7613(00)00072-8
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发表时间：
2000-11-01
期刊：
影响因子：
32.4
通讯作者：
Imler, JL
中科院分区：
文献类型：
--
作者：
Tzou, P;Ohresser, S;Imler, JL
抗菌肽的产生是多细胞生物中宿主防御的一个重要方面。在果蝇体内，脂肪体在免疫应答过程中合成7种具有不同活性谱的抗菌肽，并分泌到血淋巴中。使用GFP报告转基因，我们在这里表明，所有七个果蝇抗菌肽可以诱导在表面上皮细胞在组织特异性的方式。imd基因在激活这种对感染的局部反应中起着关键作用。特别是，在全身反应期间由Toll途径调节的drosomycin表达在呼吸道中由imd调节，从而证明了在果蝇中存在局部和全身诱导抗菌肽基因的不同调节机制。
The production of antimicrobial peptides is an important aspect of host defense in multicellular organisms. In Drosophila, seven antimicrobial peptides with different spectra of activities are synthesized by the fat body during the immune response and secreted into the hemolymph. Using GFP reporter transgenes, we show here that all seven Drosophila antimicrobial peptides can be induced in surface epithelia in a tissue-specific manner. The imd gene plays a critical role in the activation of this local response to infection. In particular, drosomycin expression, which is regulated by the Toll pathway during the systemic response, is regulated by imd in the respiratory tract, thus demonstrating the existence of distinct regulatory mechanisms for local and systemic induction of antimicrobial peptide genes in Drosophila.