SUNLIGHT AND BREAST-CANCER INCIDENCE IN THE USSR
SUNLIGHT AND BREAST-CANCER INCIDENCE IN THE USSR
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DOI：
10.1093/ije/19.4.820
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发表时间：
1990-12-01
影响因子：
7.7
通讯作者：
GARLAND, CF
中科院分区：
文献类型：
--
作者：
GORHAM, ED;GARLAND, FC;GARLAND, CF
流行病学和实验室证据表明，维生素D可能在降低乳腺癌风险方面发挥作用。缺乏紫外线照射会增加维生素D缺乏症的患病率，并可能使某些人群患乳腺癌的风险更高。研究人员评估了苏联年平均照射地面的太阳总能量与年龄调整后的乳腺癌发病率之间的关系。乳腺癌的发病率是其他疾病的三倍。阳光水平从每天每平方厘米210到400卡路里不等。乳腺癌发病率与总日照水平之间存在统计学显著负相关（R =-0.75，p = 0.001）。回归线的斜率对应于每平方厘米阳光每减少35卡路里，每年每100 000人增加2例。苏联低太阳辐射地区乳腺癌发病率增加的模式与美国和全球乳腺癌死亡率的地理模式一致。根据大约的社会经济指标（每1000人的医生数量），苏联的社会经济状况与乳腺癌发病率之间也存在正相关关系（R =+0.89，p =0.0001）。相关的社会经济地位，如饮食，种族，或行为因素，可以占协会的可能性进行了讨论。
Epidemiological and laboratory evidence suggest that vitamin D may play a role in reducing risk of breast cancer. Lack of exposure to ultraviolet sunlight can increase the prevalence of vitamin D deficiency, and may place some populations at higher risk of breast cancer. The association between total average annual sunlight energy striking the ground and age-adjusted breast cancer incidence rates in the USSR was evaluated. Breast cancer had a threefold range of incidence. Sunlight levels varied from 210 to 400 calories per cm2 per day. A statistically significant negative association was found between breast cancer incidence rates and total sunlight levels (R = -0.75, p = 0.001). The slope of the regression line corresponded to two additional cases per 100 000 per year for each reduction of 35 calories per cm2 of sunlight. The pattern of increased breast cancer incidence in regions of low solar radiation in the USSR is consistent with the geographical pattern seen for breast cancer mortality in the US and worldwide. A positive relationship between socioeconomic status and breast cancer incidence was also present in the Soviet Union, based on an approximate socioeconomic measure, the number of doctors per 1000 population (R = +0.89, p = 0.0001). The possibility that correlates of socioeconomic status, such as dietary, ethnic, or behavioural factors, could account for the association is discussed.