Influence of the route of administration on the protective effect of L-carnitine on acute hyperammonemia.
Influence of the route of administration on the protective effect of L-carnitine on acute hyperammonemia.
复制标题
给药途径对左旋肉碱对急性高氨血症保护作用的影响。
DOI：
10.1016/0006-2952(86)90407-7
复制
发表时间：
1986
影响因子：
5.8
通讯作者：
S. Grisolía
中科院分区：
文献类型：
--
作者：
J. O'connor;M. Costell;M. Míguez;S. Grisolía
Fig. 2. Movement of surface-bound [* 251] transferrin into cells and medium when incubated at 37” without (upper panel) and with 0.5 mM ANS (lower panel). The radioactivity in the pronase-resistant fraction (AA), the pronase-sensitive fraction (O----O) and the medium (Oe---. O) was determined as described in the text. tors and the association constant of the receptors for transferrin (K,), although only the latter was significantly different at 1 mM ANS concentration. Subsequently, the rate of iron uptake was also reduced. It is unlikely that ANS was in direct competition with the protein for binding sites as the probe inhibited the binding of transferrin in a non-competitive manner (unpublished data). Also, ANS binds to the hydrophobic region of the erythrocyte membrane spanning from the outer cell surface to some discrete areas of the inner surfaces [9]. As the transferrin receptors are not hydrophobic [lo], it is doubtful that the membrane probe could have occupied a part, or all, of the transferrin
