[Physiological variation of oxytocin in normal females and males: relation of estrogen, progesterone, testosterone and LH-RH to oxytocin secretion (author's transl)].
[Physiological variation of oxytocin in normal females and males: relation of estrogen, progesterone, testosterone and LH-RH to oxytocin secretion (author's transl)].
复制标题
[正常女性和男性催产素的生理变化：雌激素、孕激素、睾酮和 LH-RH 与催产素分泌的关系（作者翻译）]。
DOI：
10.1507/endocrine1927.56.9_1182
复制
发表时间：
1980
期刊：
影响因子：
--
通讯作者：
S. Ogawa
中科院分区：
文献类型：
--
作者：
S. Ogawa
为了阐明催产素分泌的昼夜节律及其与雌激素、孕酮、睾酮和促黄体生成素释放激素的关系，测定了正常和性腺功能减退者应用这些激素前后的血浆催产素水平。研究结果如下：(1)月经周期正常的女性，隔夜禁食后清晨血浆催产素水平卵泡期(4.5±2.6pg/ml)显著高于黄体期(2.1±1.3pg/ml)(p<；0.01)。卵泡期和排卵期血浆催产素水平高于黄体期。黄体期催产素平均浓度睡眠期高于清醒期，卵泡期清醒时高于睡眠期。(2)健康男性隔夜禁食后清晨血浆催产素水平为3.5±1.7pg/ml，睡眠时高于清醒时。但清醒时血浆催产素水平的变化大于睡眠时。血浆催产素水平在一年中没有周期性变化，但夏季高于冬季。(3)正常男女血浆催产素水平在雌二醇作用后显著升高，孕酮作用后无明显变化，雌二醇组和雌激素组血浆催产素水平无明显变化。
In order to elucidate the diurnal and circadian rhythms of oxytocin secretion, and the relation of estrogen, progesterone, testosterone and LH-RH to oxytocin secretion, plasma oxytocin levels were determined before and after the administration of these hormones in normal and hypogonadal subjects. The results were as follows. (1) In females with normal menstrual cycle, plasma oxytocin levels in the morning after overnight fasting were significantly higher (4.5 ± 2.6 pg/ml (mean ± SE)) in the follicular phase than they were (2.1 ± 1.3 pg/ml) in the luteal phase (p<0.01). Plasma oxytocin levels were higher in the follicular and ovulatory phases than they were in the luteal phase. In the luteal phase, the mean oxytocin concentration was higher during sleeping than during waking; however, in the follicular phase a variation of plasma oxytocin level was higher during waking than during sleeping. (2) In healthy males, plasma oxytocin level in the morning after overnight fasting was 3.5 ± 1.7 pg/ml, which was higher during sleeping than during waking. But the variation of plasma oxytocin levels during waking was larger than that during sleeping. Plasma oxytocin levels did not show cyclic changes in a year, but they were higher in summer than in winter. (3) Plasma oxytocin levels rose significantly after estradiol administration in normal females and males and did not change significantly after progesterone, and estradiol and