[Technical limitations of the positron emission tomography (PET) for small laboratory animals].
[Technical limitations of the positron emission tomography (PET) for small laboratory animals].
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DOI：
10.1157/13079288
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发表时间：
2005-09-01
影响因子：
--
通讯作者：
Desco, M
中科院分区：
文献类型：
--
作者：
Vaquero, J J;Desco, M
通过PET在小型实验室动物中对器官功能进行可视化和定量正在成为表征转基因和基因敲除动物的表型、研究人类疾病的动物模型以及开发新的治疗药物和诊断生化探针的杰出工具。为了能够以与人类相同的方式将PET用于小型实验室动物，必须考虑体积比例因子以及维持计数统计的要求。这项工作勾勒出的问题，这些要求代表的扫描仪的技术设计和执行的实验。最后，简要讨论了商用扫描仪（microPET/ FOCUS、HiDAC、eXplore VISTA、MOSAIC、雅普-（S）PET和rPET）的一些特性。
Visualization and quantification of organ function by PET in small laboratory animals is becoming an outstanding tool for characterization of phenotype of transgenic and knock-out animals, for the study of animal models of human diseases, and for the development of new therapeutic drugs and diagnostic biochemical probes. To be able to make use of the PET with small laboratory animals in the same way as it is operated with humans it is necessary to account for the volumetric scale factor as well as for the requirement of maintaining the counting statistics. This work sketches the problems that these requirements represent for the technical design of the scanners and for the execution of the experiments. Finally, some characteristics of commercially available scanners (microPET/ FOCUS, HiDAC, eXplore VISTA, MOSAIC, YAP-(S)PET and rPET) are briefly discussed.