Placental Pathology in Down Syndrome-Associated Transient Abnormal Myelopoiesis.
Placental Pathology in Down Syndrome-Associated Transient Abnormal Myelopoiesis.
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唐氏综合症相关短暂性异常骨髓生成的胎盘病理学。
DOI：
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发表时间：
2020
影响因子：
4.6
通讯作者：
Asangi R. Kumarapeli
中科院分区：
文献类型：
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作者：
Enoch Kuo;Asangi R. Kumarapeli
短暂性骨髓增生异常是一种造血功能紊乱，在唐氏综合征新生儿中发生率高达10%。它的特点是白细胞增多和循环母细胞的存在，这些母细胞含有截断的GATA1突变，并涉及可变的多器官系统。短暂性异常骨髓增生累及胎盘的报道并不多见。胎盘检查和识别与短暂性骨髓增生异常相关的特征可能是诊断死产、早产儿和部分无症状新生儿的早期手段之一，如果不是唯一的手段。本文综述了一过性骨髓增生异常的胎盘病理，并对其重要的鉴别诊断进行了讨论。
Transient abnormal myelopoiesis is a hematopoietic disorder that occurs in up to 10% of neonates with Down syndrome. It is characterized by leukocytosis and the presence of circulating blast cells harboring truncating GATA1 mutations with variable multiorgan system involvement. Placental involvement of transient abnormal myelopoiesis is infrequently described. Placental examination and identifying features related to transient abnormal myelopoiesis could be one of the early, if not the only, means of diagnosis of this condition in affected stillbirths, premature infants, and a subset of asymptomatic neonates. This article provides an overview of the placental pathology in transient abnormal myelopoiesis with review of the literature, and also discusses the important differential diagnoses.
影响因子：
20.3
作者：
Klusmann, Jan-Henning;Creutzig, Ursula;Reinhardt, Dirk
通讯作者：
Reinhardt, Dirk