Neutrophil transendothelial migration and alteration in vascular permeability: focus on neutrophil-derived azurocidin
Neutrophil transendothelial migration and alteration in vascular permeability: focus on neutrophil-derived azurocidin
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DOI：
10.1097/00062752-200301000-00005
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发表时间：
2003-01-01
影响因子：
3.2
通讯作者：
Parkos, CA
中科院分区：
文献类型：
--
作者：
Edens, HA;Parkos, CA
组织内多形核白细胞的渗入和积聚是急性炎症反应的特征。急性炎症的一个显著特征是血管通透性增强，导致水肿形成。已知血管通透性的这种变化依赖于多形核白细胞与血管内皮细胞的相互作用。仔细的研究清楚地表明，在没有多形核白细胞经内皮细胞迁移的情况下，可以发生通透性的变化，并且在没有通透性变化的情况下，可以发生多形核白细胞的迁移。中性粒细胞刺激内皮细胞屏障功能改变的潜在机制仍不清楚。多形核白细胞引起的血管通透性改变需要内皮激活和多形核白细胞与内皮的黏附。多形核白细胞衍生的天青杀菌素在这种多形核白细胞引起的内皮通透性改变中起主要作用。杀天青素是在多形核白细胞激活后释放的，例如在连接主要黏附的整合素CD11b/CD18之后。了解多形核白细胞如何改变血管通透性，可能为急慢性炎症性疾病的适当治疗干预提供新药靶点。本文就多形核白细胞衍生的天青素在血管通透性改变中的作用作一综述。(C)2003年Lippincott Williams Wilkins，Inc.
Infiltration and accumulation of polymorphonuclear leukocytes within the tissues is a hallmark of the acute inflammatory response. A prominent feature of acute inflammation is enhanced vascular permeability resulting in edema formation. Such changes in vascular permeability have been known to be dependent upon polymorphonuclear leukocyte interactions with the vascular endothelium. Careful investigation has shown clearly that permeability changes can occur without polymorphonuclear leukocyte transendothelial migration, and that polymorphonuclear leukocyte migration can occur without permeability alteration. The underlying mechanisms of polymorphonuclear leukocyte-stimulated changes in endothelial barrier function have remained elusive. Endothelial activation and polymorphonuclear leukocyte adhesion to the endothelium are both required for polymorphonuclear leukocyte-induced changes in vascular permeability. Polymorphonuclear leukocyte-derived azurocidin plays a major role in this polymorphonuclear leukocyte-evoked alteration in endothelial permeability. Azurocidin is released after activation of polymorphonuclear leukocytes, such as after ligation of the major adhesive integrin CD11b/CD18. Understanding how polymorphonuclear leukocytes alter vascular permeability may provide targets for new drugs for appropriate therapeutic intervention in acute and chronic inflammatory diseases. This review focuses on the role of polymorphonuclear leukocyte-derived azurocidin in alteration of vascular permeability. (C) 2003 Lippincott Williams Wilkins, Inc.