Perturbations in the model of estrogen receptor regulation of gene expression.
Perturbations in the model of estrogen receptor regulation of gene expression.
复制标题
雌激素受体基因表达调节模型的扰动。
DOI：
10.1095/biolreprod48.1.8
复制
发表时间：
1993
影响因子：
3.6
通讯作者：
Malayer,JR
中科院分区：
文献类型：
--
作者：
Gorski,J;Furlow,JD;Murdoch,FE;Fritsch,M;Kaneko,K;Ying,C;Malayer,JR
雌激素受体是雌激素作用机制中的关键元件。雌激素及其受体如何相互作用并随后改变基因表达的模型应该重新评估，以解释目前可用的新数据。下面的综述讨论了雌激素结合引起的雌激素受体的核定位、DNA结合和蛋白质结构变化。我们还讨论了这些现象如何与基因表达变化的诱导有关。
Estrogen receptors are key elements in the mechanisms of action of estrogenic hormones. Models of how estrogens and their receptors interact and subsequently modify gene expression should be reevaluated to explain new data currently available. The following review discusses nuclear localization, DNA binding, and protein structural changes of the estrogen receptor induced by estrogen binding. We also discuss how these phenomena relate to the induction of changes in gene expression.