Increased Expression of the Glucose Transporter Type 1 Gene Is Associated With Worse Overall Survival in Resected Pancreatic Adenocarcinoma.
Increased Expression of the Glucose Transporter Type 1 Gene Is Associated With Worse Overall Survival in Resected Pancreatic Adenocarcinoma.
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DOI：
10.1097/mpa.0000000000000580
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发表时间：
2016-08
期刊：
影响因子：
2.9
通讯作者：
Malafa MP
中科院分区：
文献类型：
--
作者：
Davis-Yadley AH;Abbott AM;Pimiento JM;Chen DT;Malafa MP
目前还没有可靠的方法来预测早期胰腺癌根治性切除后复发的风险。在18F-脱氧葡萄糖正电子发射断层扫描(PET)上观察到恶性细胞葡萄糖代谢增加，即Warburg效应，这是众所周知的恶性表型的特征。我们研究了葡萄糖转运蛋白1(GLUT-1)基因表达在早期胰腺癌中的作用。研究早期胰腺癌患者GLUT-1基因表达与PET最大标准摄取值(SUVmax)和组织学分级的关系。采用多因素分析确定影响预后的因素。生存分析采用COX比例风险模型。63例患者进行了GLUT-1基因分析，50例患者同时进行了GLUT-1分析和PET扫描。COX比例风险模型单因素分析显示，GLUT-1基因高表达患者的总生存率降低(HR=2.82，p=0.001)，但在多因素分析中仍具有统计学意义(HR=2.54，p=0.03)。GLUT-1基因的表达与组织学分级及PETSUVmax无关。GLUT-1基因表达增加与胰腺癌总存活率降低有关。这支持GLUT-1基因表达增加可作为胰腺癌切除后潜在的预后指标。
There is currently no reliable method to predict the risk of relapse after curative resection of early-stage pancreatic adenocarcinoma. Increased glucose metabolism observed on 18F-fluorodeoxyglucose positron emission tomography (PET) by malignant cells, the Warburg effect, is a well-known characteristic of the malignant phenotype. We investigated the role of glucose transporter type 1 (GLUT-1) gene expression, a glucose cell plasma membrane transporter, in early-stage pancreatic cancer. Associations between GLUT-1 gene expression with PET maximum standardized uptake values (SUVmax) and histologic grade were investigated in early-stage pancreatic adenocarcinoma patients. Multivariate analysis was conducted to determine predictors of prognosis. Cox proportional hazards model was used for survival analysis. Sixty-three patients had GLUT-1 gene analysis performed, and 50 patients had both GLUT-1 analysis and PET scan. Patients with high GLUT-1 gene expression had a decreased overall survival by univariate analysis using Cox proportional hazards model (HR=2.82, p=0.001) and remained significant on multivariate analysis (HR=2.54, p=0.03). There was no correlation of GLUT-1 gene expression with histologic grade or PET SUVmax. Increased GLUT-1 gene expression was associated with a decreased overall survival in pancreatic adenocarcinoma. This supports increased GLUT-1 gene expression as a potential prognostic marker in resected pancreatic adenocarcinoma.