Dual Functional Small Molecule Probes as Fluorophore and Ligand for Misfolding Proteins.
Dual Functional Small Molecule Probes as Fluorophore and Ligand for Misfolding Proteins.
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DOI：
10.2174/1385272811317060004
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发表时间：
2013-03-01
影响因子：
2.6
通讯作者：
Ran C
中科院分区：
文献类型：
--
作者：
Zhang X;Ran C
蛋白质的错误折叠是多种疾病的破坏性过程，所述疾病包括神经退行性疾病如阿尔茨海默病、帕金森病、亨廷顿病、疯牛病、肌萎缩侧索硬化症（ALS）和额颞叶痴呆（FTD），以及其它非CNS疾病如糖尿病、囊性纤维化和溶酶体贮积病。错误折叠蛋白质的各种功能错误的大组装体的形成是主要后果。检测聚集态的形成，不仅对基础机理研究十分重要，而且对疾病的诊断也十分关键。本文综述了近年来国内外研究开发的用于检测蛋白质聚集体的双功能荧光小分子探针。
Misfolding of a protein is a destructive process for variety of diseases that include neurodegenerative diseases such as Alzheimer’s disease, Parkinson disease, Huntington disease, mad cow disease, amyotrophic lateral sclerosis (ALS), and frontal temporal dementia (FTD), and other non-CNS diseases such as diabetes, cystic fibrosis, and lysosomal storage diseases. Formation of various misfunctional large assembles of the misfolded protein is the primary consequence. To detect the formation of the aggregated species is very important for not only basic mechanism research but also very crucial for diagnosis of the diseases. In this review, we updated references related to the new development of the dual functional fluorescent small molecule probes for detecting the aggregated proteins in vitro and in vivo.
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DOI：
10.1016/j.bbapap.2010.04.001
发表时间：
2010-07
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Biancalana M;Koide S
通讯作者：
Koide S
影响因子：
3.4
作者：
Celej, M. Soledad;Jares-Erijman, Elizabeth A.;Jovin, Thomas M.
通讯作者：
Jovin, Thomas M.
影响因子：
64.8
作者：
Alavez, Silvestre;Vantipalli, Maithili C.;Zucker, David J. S.;Klang, Ida M.;Lithgow, Gordon J.
通讯作者：
Lithgow, Gordon J.
影响因子：
11.5
作者：
Aggarwal, BB;Shishodia, S;Price, JE
通讯作者：
Price, JE
影响因子：
3.6
作者：
Aggarwal, S;Ichikawa, H;Aggarwal, BB
通讯作者：
Aggarwal, BB