Theophylline blocks ethanol withdrawal-induced hyperalgesia.
Theophylline blocks ethanol withdrawal-induced hyperalgesia.
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茶碱可阻断乙醇戒断引起的痛觉过敏。
DOI：
10.1093/alcalc/37.4.313
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Selvig,Meghan
中科院分区：
文献类型：
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作者：
Gatch,MichaelB;Selvig,Meghan
方法：在四组大鼠中测试乙醇的慢性作用，这些大鼠接受10天暴露于液体饮食{单独的乙醇或与茶碱[0.5和1.0 mg/kg，每天两次，腹膜内（i. p.）]，和糊精控制饮食}。在去除液体饮食后12小时测试乙醇戒断。累积剂量的非选择性腺苷激动剂2-氯腺苷（2-CADO; 0.6-10 mg/kg，i. p.）结果：慢性乙醇暴露可产生抗伤害性感受，且在戒断过程中可观察到痛觉过敏。亚慢性施用茶碱（0.5-1.0 mg/kg，每日两次，i. p.）剂量依赖性地防止乙醇戒断诱导的痛觉过敏。在乙醇戒断，2-CADO是不太有力的比当给予非依赖性大鼠，这种效果被阻止了茶碱（1.0毫克/公斤）的亚慢性给药。结论：这些研究结果提供了行为的证据与早期的工作一致的作用，腺苷在乙醇耐受性和撤回的发展，并建议腺苷受体在乙醇戒断过程中的痛觉过敏的发展中发挥重要作用。
—Aims:This study examined the effects of theophylline on the hyperalgesia produced by ethanol withdrawal using a radiant heat tail-flick assay.Methods:Chronic effects of ethanol were tested in four groups of rats which received 10 days exposure to a liquid diet {ethanol alone or with theophylline [0.5 and 1.0 mg/kg, twice daily, intraperitoneally (i.p.)], and dextrin control diet}. Ethanol withdrawal was tested 12 h after removal of the liquid diet. Effects of cumulative doses of the non-selective adenosine agonist 2-chloroadenosine (2-CADO; 0.6–10 mg/kg, i.p.) were tested during withdrawal in the ethanol-treated groups.Results:Chronic exposure to ethanol produced antinociception, and hyperalgesia was seen during withdrawal. Subchronic administration of theophylline (0.5–1.0 mg/kg, twice daily, i.p.) dose-dependently prevented the ethanol-withdrawal-induced hyperalgesia. During ethanol withdrawal, 2-CADO was less potent than when given to non-dependent rats and this effect was prevented by subchronic administration of theophylline (1.0 mg/kg).Conclusions:These findings provide behavioural evidence in agreement with earlier work on the role of adenosine in the development of ethanol tolerance and withdrawal, and suggest that adenosine receptors play an important role in the development of hyperalgesia during ethanol withdrawal.