Cross-linking of the extracellular matrix by the Maillard reaction in aging and diabetes - An update on "a puzzle nearing resolution"
Cross-linking of the extracellular matrix by the Maillard reaction in aging and diabetes - An update on "a puzzle nearing resolution"
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DOI：
10.1196/annals.1333.061
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发表时间：
2005-01-01
期刊：
影响因子：
--
通讯作者：
Sell, DR
中科院分区：
文献类型：
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作者：
Monnier, VM;Mustata, GT;Sell, DR
老化的细胞外基质的特征在于与年龄相关的不溶性增加、变黄和变硬，所有这些都可以通过体外美拉德反应来模拟。这些现象在代谢性疾病如糖尿病和终末期肾病中加速，其与生理性衰老共同具有各种糖化产物和交联的积累。八年前，我们得出结论，证据支持实验性糖尿病中的氧化交联[Monnier，V.M.等，1996年。糖尿病中胶原交联的机制：一个接近完成的谜题。Diabetes 45（Suppl.3）：67-72]，并提出了衍生自葡萄糖的推定的非UV活性交联的主要作用。下面，我们提供了该领域的更新，得出的结论是，虽然氧化可能是重要的美拉德反应介导的交联通过Strecker降解和赖氨酸的形成，单一的最重要的胶原交联已知的糖尿病和老化是glucosepane，赖氨酰精氨酸交联下形成的非氧化条件。
The aging extracellular matrix is characterized by an age-related increase in insolubilization, yellowing, and stiffening, all of which can be mimicked by the Maillard reaction in vitro. These phenomena are accelerated in metabolic diseases such as diabetes and end-stage renal disease, which have in common with physiological aging the accumulation of various glycation products and cross-links. Eight years ago we concluded that the evidence favored oxidative cross-linking in experimental diabetes [Monnier, V.M. et al. 1996. The mechanism of collagen cross-linking in diabetes: a puzzle nearing completion. Diabetes 45(Suppl. 3): 67-72] and proposed a major role for a putative non-UV active cross-link derived from glucose. Below, we provide an update of the field that leads to the conclusion that, while oxidation might be important for Maillard reaction-mediated cross-linking via Strecker degradation and allysine formation, the single most important collagen cross-link known to date in diabetes and aging is glucosepane, a lysyl-arginine cross-link that forms under nonoxidative conditions.