Circadian and ultradian rhythms in cardiac autonomic modulation.
Circadian and ultradian rhythms in cardiac autonomic modulation.
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心脏自主调节中的昼夜节律和超昼夜节律。
DOI：
10.1109/iembs.2006.259558
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发表时间：
2006
期刊：
影响因子：
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通讯作者：
Domitrovich,PeterP
中科院分区：
文献类型：
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作者：
Stein,PhyllisK;Lundequam,EricJ;Clauw,Daniel;Freedland,KennethE;Carney,RobertM;Domitrovich,PeterP
心跳之间的时间长度由窦房结的去极化速率控制。该速率由交感神经和副交感神经输入的组合控制。因此，对正常心跳间隔得出的心率 (HR) 和心率变异性 (HRV) 进行分析可以深入了解心脏自主功能的变化。从一个时间点到下一时间点增强心脏的交感神经控制往往会增加 HR，减少以高频 (HF) 频谱功率测量的迷走神经调节窦性心律失常量，并增加低频 (LF) 频谱功率与 HF 之间的比率（LF/HF 比率）。相反，向心脏更大的迷走神经控制的转变往往会导致心率降低、高频功率增加，并降低低频/高频比。大多数受试者都可以看到清晰的 HR 和 HRV 昼夜节律周期，并且与睡眠和活动周期相对应。这些周期的大小可以通过传统 HRV 指数很好地捕捉到，例如所有正常与正常 (NN) 间隔的偏差。余弦分析还提供了昼夜节律幅度的粗略估计。我们观察到，大多数受试者的 HR 和 HRV 随时间呈周期性波动。尽管这些周期在夜间尤其明显，但它们也在白天出现。我们已经制定了许多量化 HR/HRV 周期的超电特性的措施，并允许在受试者之间进行比较。我们在夜间多导睡眠监测中应用了这些措施，并表明心脏自主调节的超电节律与传统睡眠阶段具有可变且通常较弱的对应关系。在当前的研究中，我们将针对夜间记录开发的方法应用于年轻健康受试者的 24 小时记录，并将这些结果与仅在同一受试者和老年心脏病患者夜间获得的结果进行比较。我们的目的是探索现状
The amount of time between heartbeats is controlled by the rate of depolarization of the sinoatrial node. This rate is controlled by a combination of sympathetic and parasympathetic inputs. For this reason, analysis of heart rate (HR) and heart rate variability (HRV) derived from intervals between normal heart beats provides insights into changing cardiac autonomic function. Increased sympathetic control of the heart from one time point to the next tends to increase HRs, decrease the amount of vagally modulated sinus arrhythmia measured as high-frequency (HF) spectral power, and increase the ratio between low-frequency (LF) spectral power and HF (the LF/HF ratio). Conversely, a shift toward greater vagal control of the heart tends to produce decreased HRs, increases in HF power, and decreases the LF/HF ratio. Clear circadian cycles of HR and HRV are seen in most subjects and correspond to periods of sleep and activity. The magnitude of these cycles is well captured by traditional HRV indices such as deviation of all normal-to-normal (NN) intervals. Cosinor analysis also provides a rough estimate of the magnitude of circadian rhythms. We have observed that HR and HRV fluctuate over time in a cyclic manner in most subjects. Although these cycles are especially prominent during the nighttime, they are seen in the daytime as well. We have developed a number of measures that quantify ultradian properties of HR/HRV cycles and would permit comparisons between subjects. We applied these measures during overnight polysomnography and have shown that ultradian rhythms of cardiac autonomic modulation have a variable and often weak correspondence with traditional sleep stages . In the current study, we applied the methodology developed for the nighttime recordings to 24-h recordings in young healthy subjects and compared these results to those obtained during the nighttime only in the same subjects and in an older group of cardiac patients. Our purpose was to explore the presenc