Prenyleudesmanes and A Hexanorlanostane from the Roots of Lonicera macranthoides
Prenyleudesmanes and A Hexanorlanostane from the Roots of Lonicera macranthoides
复制标题
毛忍冬根中的异戊二烯烯和己酰羊毛甾烷
DOI：
10.3390/molecules24234276
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发表时间：
2019-12-01
期刊：
影响因子：
4.6
通讯作者：
Chen, Yu
中科院分区：
文献类型：
--
作者：
Lyu, Hui;Liu, Wenjuan;Chen, Yu
从灰毡毛忍冬（Escheramacranthoides）的根中分离得到三个以前未描述的化合物，两个异戊基去氧烷（1和2）和一个己降羊毛烷（3）。通过一维和二维核磁共振（NMR）谱和高分辨电喷雾电离质谱（HR-ESI-MS）数据确定了它们的结构。用X射线衍射法测定了化合物1和3的绝对构型。据我们所知，这是第一次通过单晶X射线衍射和Cu Kα辐射明确证实了具有反式十氢化萘系统和六降羊毛烷的异戊基去氧烷的绝对构型。测试化合物对癌细胞系（HepG 2和HeLa）的抗增殖活性。化合物1-3对两种人癌细胞系表现出中等的抑制作用。
Three previously undescribed compounds, two prenyleudesmanes (1 and 2), and one hexanorlanostane (3), were isolated from the roots of Lonicera macranthoides. Their structures were established based on 1D and 2D nuclear magnetic resonance (NMR) spectra and high-resolution electrospray ionization mass spectral (HR-ESI-MS) data. The absolute configurations of 1 and 3 were determined by X-ray diffraction. To the best of our knowledge, this is the first time that the absolute configuration of a prenyleudesmane with a trans-decalin system and a hexanorlanostane have been unambiguously confirmed by single-crystal X-ray diffraction with Cu Kα radiation. Thecompounds were tested for their antiproliferative activity on the cancer cell lines (HepG2 and HeLa). The compounds 1–3 exhibited moderate inhibitory effects against two human cancer cell lines.