Hematopoietic and lymphatic cancers in relatives of patients with infectious mononucleosis.
Hematopoietic and lymphatic cancers in relatives of patients with infectious mononucleosis.
复制标题
传染性单核细胞增多症患者亲属的造血系统和淋巴癌。
DOI：
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发表时间：
2002
期刊：
影响因子：
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通讯作者：
M. Melbye
中科院分区：
文献类型：
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作者：
H. Hjalgrim;K. Rostgaard;J. Askling;M. Madsen;H. Storm;C. Rabkin;M. Melbye
背景
有EB病毒相关传染性单核细胞增多症病史的年轻人患霍奇金淋巴瘤的风险增加。在一些患者的霍奇金淋巴瘤Reed-Sternberg细胞中检测到EBV，但在年轻成人患者的这些细胞中检测到EBV的频率相对较低。霍奇金淋巴瘤和传染性单核细胞增多症都与高社会阶层有关，未知的混杂因素也与社会经济地位有关，可能解释或促成这些疾病之间的明显联系。为了间接评估社会经济地位对这些疾病之间联系的重要性，我们确定了确诊的EBV相关传染性单核细胞增多症患者的一级亲属患造血癌和淋巴癌的风险。
方法
我们确定了17,045名血清学确诊的EBV相关传染性单核细胞增多症患者的父母、兄弟姐妹和子女。在指标患者被诊断为传染性单核细胞增多症后，这些队列中的受试者与以人群为基础的丹麦癌症登记系统联系起来，以确定哪些人患上了造血/淋巴癌。传染性单核细胞增多症家族成员患癌症的相对风险以标准化发病率(SIRS)表示，即观察到的癌症数量与预期癌症数量之间的比率，从年龄、性别和时期特定的发病率获得)。
结果
我们确定了EB病毒相关传染性单核细胞增多症患者的8052名父母、5264名兄弟姐妹和28,605名子女，他们总共被跟踪了892,213人年的风险。这些患者的一级亲属合并组(SIR=0.99；95%可信区间[95%CI]=0.62至1.59；病例数[n]=17)、父母组(SIR=0.83；95%CI=0.31至2.22；n=4)、兄弟姐妹组(SIR=0.96；95%CI=0.31至2.97；n=3)以及子女组(SIR=1.08；95%CI=0.58~2.02；n=10)。
结论
EBV相关传染性单核细胞增多症患者的家庭成员患霍奇金淋巴瘤的风险并不显著，这表明社会经济混杂不太可能解释EBV相关传染性单核细胞增多症与霍奇金淋巴瘤之间的联系。
BACKGROUND
Young adults with a history of Epstein-Barr virus (EBV)-related infectious mononucleosis have an increased risk for Hodgkin's lymphoma. EBV is detected in Hodgkin's lymphoma Reed-Sternberg cells from some patients, but in young adult patients, it is detected at a relatively low frequency in these cells. Hodgkin's lymphoma and infectious mononucleosis are both associated with high social class, and unknown confounding factors that are also associated with socioeconomic status might explain or contribute to the apparent association between these diseases. To indirectly assess the importance of socioeconomic status on the association between these diseases, we determined the risk for hematopoietic and lymphatic cancers in first-degree relatives of patients with confirmed EBV-related infectious mononucleosis.
METHODS
We identified parents, siblings, and offspring of 17,045 persons with serologically confirmed EBV-related infectious mononucleosis. Subjects in these cohorts were linked with the population-based Danish Cancer Register to identify those developing hematopoietic/lymphatic cancers after the index patient was diagnosed with infectious mononucleosis. The relative risk for cancer in the infectious mononucleosis family members was expressed as standardized incidence ratios (SIRs; i.e., the ratio between the number of cancers observed and the number of cancers expected, obtained from age-specific, sex-specific, and period-specific incidence rates).
RESULTS
We identified 8052 parents, 5264 siblings, and 28,605 offspring of patients with EBV-related infectious mononucleosis who were followed for a total of 892,213 person-years at risk. The risk for Hodgkin's lymphoma was unaltered in the combined group of first-degree relatives of these patients (SIR = 0.99; 95% confidence interval [95% CI] = 0.62 to 1.59; number of cases [n] = 17), in the group of parents (SIR = 0.83; 95% CI = 0.31 to 2.22; n = 4), in the group of siblings (SIR = 0.96; 95% CI = 0.31 to 2.97; n = 3), and in the group of offspring (SIR = 1.08; 95% CI = 0.58 to 2.02; n = 10).
CONCLUSION
The unremarkable risk for Hodgkin's lymphoma in family members of patients with EBV-related infectious mononucleosis indicates that socioeconomic confounding is an unlikely explanation for the association between EBV-related infectious mononucleosis and Hodgkin's lymphoma.
霍奇金病中的 Epstein-Barr 病毒：危险因素和疾病特征与病毒感染分子证据的相关性。
DOI：
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发表时间：
1998
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
影响因子：
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作者：
Sleckman,BG;Mauch,PM;Ambinder,RF;Mann,R;Pinkus,GS;Kadin,ME;Sherburne,B;Perez-Atayde,A;Thior,I;Mueller,N
通讯作者：
Mueller,N