Body Composition Findings by Computed Tomography in SARS-CoV-2 Patients: Increased Risk of Muscle Wasting in Obesity
Body Composition Findings by Computed Tomography in SARS-CoV-2 Patients: Increased Risk of Muscle Wasting in Obesity
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DOI：
10.3390/ijms21134670
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发表时间：
2020-07-01
影响因子：
5.6
通讯作者：
De Lorenzo, Antonino
中科院分区：
文献类型：
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作者：
Gualtieri, Paola;Falcone, Carmela;De Lorenzo, Antonino
肥胖是 COVID-19 患者的一个特征，由于脂肪过多，营养不良的风险可能被低估：这是一种矛盾的危险。长期 ICU 住院使患者面临消瘦和瘦体重损失的高风险。复杂的管理无法检测用于定义和监测营养状况的人体测量参数。使用身体成分成像诊断可以帮助通过有针对性的途径识别和治疗消瘦风险增加的患者。入住 ICU 的 COVID-19 患者在 24 小时内和约 20 天后接受计算机断层扫描，以评估身体和肝脏成分的参数。主要结果是肥胖受试者的去脂质量指数下降，肝脏衰减更大。这些可能是由 COVID-19、长时间卧床、复杂的医学营养疗法以及肥胖者低度炎症的起始条件共同引起的。对营养状况的评估，以及将身体成分应用于 COVID-19 的影像诊断和代谢特征，将有助于制定适当的医疗营养治疗。这将减少恢复时间和因虚弱引起的并发症。
Obesity is a characteristic of COVID-19 patients and the risk of malnutrition can be underestimated due to excess of fat: a paradoxical danger. Long ICU hospitalization exposes patients to a high risk of wasting and loss of lean body mass. The complex management precludes the detection of anthropometric parameters for the definition and monitoring of the nutritional status. The use of imaging diagnostics for body composition could help to recognize and treat patients at increased risk of wasting with targeted pathways. COVID-19 patients admitted to the ICU underwent computed tomography within 24 h and about 20 days later, to evaluate the parameters of the body and liver composition. The main results were the loss of the lean mass index and a greater increase in liver attenuation in obese subjects. These could be co-caused by COVID-19, prolonged bed rest, the complex medical nutritional therapy, and the starting condition of low-grade inflammation of the obese. The assessment of nutritional status, with body composition applied to imaging diagnostics and metabolic profiles in COVID-19, will assist in prescribing appropriate medical nutritional therapy. This will reduce recovery times and complications caused by frailty.