Naphthoquinones from Onosma paniculatum with Potential Anti-inflammatory Activity
Naphthoquinones from Onosma paniculatum with Potential Anti-inflammatory Activity
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Onosma papulatum 中的萘醌具有潜在的抗炎活性
DOI：
10.1055/s-0042-120545
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发表时间：
2017-05-01
期刊：
影响因子：
2.7
通讯作者：
Li, Rong-Tao
中科院分区：
文献类型：
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作者：
Dong, Miao;Liu, Dan;Li, Rong-Tao
从滇紫草甲醇提取物中分离得到4个新的萘醌类化合物（1-4），其中包括一个二聚体化合物shikometabolin G（1）和6个已知化合物（6-10）。通过核磁共振和质谱数据分析，确定了它们的结构。评价了所有化合物对小鼠巨噬细胞RAW 264.7细胞中NO产生的抑制作用。化合物2、3、5、6、7、8和10对NO的产生有较好的抑制作用（IC_（50）= 0.4-16.5 μ M），表明化合物具有潜在的抗炎活性。
Four new naphthoquinones (1-4), including a dimeric one, shikometabolin G (1), together with six known ones (6-10), were isolated from the methanol extract of Onosma paniculatum. Their structures were established based on the analysis of NMR and MS spectroscopic data. All of the compounds were evaluated for inhibitory effects on NO production in murinemacrophage RAW264.7 cells. Compounds 2, 3, 5, 6, 7, 8, and 10 displayed good activity on the inhibition of NO production (IC50 = 0.4-16.5 mu M), suggesting the potential property of anti-inflammation.