Mood, Activity Participation, and Leisure Engagement Satisfaction (MAPLES): a randomised controlled pilot feasibility trial for low mood in acquired brain injury.
Mood, Activity Participation, and Leisure Engagement Satisfaction (MAPLES): a randomised controlled pilot feasibility trial for low mood in acquired brain injury.
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DOI：
10.1186/s40814-020-00660-8
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发表时间：
2020
影响因子：
1.7
通讯作者：
Manly T
中科院分区：
文献类型：
--
作者：
Kusec A;Murphy FC;Peers PV;Lawrence C;Cameron E;Morton C;Bateman A;Watson P;Manly T
获得性脑损伤（ABI）每年影响约7930万人，并与抑郁和情绪低落的发病率升高有关。现有的治疗ABI抑郁症的方法显示出混合的疗效。行为激活（BA）是一种潜在的有前途的干预措施。它的前提是情绪低落的人由于对积极结果的期望较低而避免计划和参与活动。因此，他们对积极强化的接触减少，加剧了情绪低落。英航旨在通过鼓励活动规划和参与来打破这种循环。目前尚不清楚传统BA的认知需求是否会破坏ABI的疗效。在这里，我们评估的可行性和可接受性的两组旨在增加活动参与。在活动计划小组（传统BA）中，将讨论有意义和积极活动的重要性，并鼓励参与者计划/参与日常生活中的活动。活动参与组（体验BA）专注于参与组内的积极体验（手工艺，游戏，讨论）。主要目的是评估两组ABI的可行性和可接受性。第二个目的是探索相对有效性的组相比，等待名单控制的同等期限。这项研究概述了一个平行臂试点的可行性试验，为个人情绪低落和ABI，比较传统与经验BA组与候补对照。将从当地ABI服务机构招募成人（≥ 18岁），并随机分配至不同条件。可行性和可接受性将通过招募、保留、出勤和参与者反馈进行评估。通过评估自我报告的活动参与度，对各组进行比较（干预前后和1个月随访）。次要结果包括抑郁、焦虑、与ABI相关的创伤后痛苦、动机、参与和对生活的控制感的自我报告测量。该试验已获得英国NHS健康研究机构的批准（英格兰东部-剑桥中心，REF 18/EE/0305）。结果将为未来关于ABI情绪干预的研究提供信息，并通过同行评审期刊，会议演示和社交媒体广泛传播。ClinicalTrials.gov，NCT 03874650预结果。方案版本2.1，2019年3月5日
Acquired brain injury (ABI) affects approximately 79.3 million individuals annually and is linked with elevated rates of depression and low mood. Existing methods for treating depression in ABI have shown mixed efficacy. Behavioural activation (BA) is a potentially promising intervention. Its premise is that individuals with low mood avoid planning and engaging in activities due to low expectations of a positive outcome. Consequently, their exposure to positive reinforcement is reduced, exacerbating low mood. BA aims to break this cycle by encouraging activity planning and engagement. It is unknown whether cognitive demands of traditional BA may undermine efficacy in ABI. Here, we assess the feasibility and acceptability of two groups designed to increase activity engagement. In the activity planning group (traditional BA), the importance of meaningful and positive activity will be discussed and participants encouraged to plan/engage in activities in everyday life. The activity engagement group (experiential BA) instead focuses on engagement in positive experiences (crafts, games, discussion) within the group. The primary aims are to evaluate the feasibility and acceptability of the two groups in ABI. A secondary aim is to explore relative efficacy of the groups compared to an equivalent period of waitlist controls. This study outlines a parallel-arm pilot feasibility trial for individuals with low mood and ABI that compares a traditional vs experiential BA group vs waitlist controls. Adults (≥ 18 years) will be recruited from local ABI services and randomised to condition. Feasibility and acceptability will be assessed via recruitment, retention, attendance and participant feedback. Groups will be compared (pre- and post-intervention and 1 month follow-up) by assessing self-reported activity engagement. Secondary outcomes include self-report measures of depression, anxiety, post-traumatic distress related to the ABI, motivation, participation and sense of control over one’s life. The trial has been approved by the Health Research Authority of the NHS in the UK (East of England—Cambridge Central, REF 18/EE/0305). Results will inform future research on interventions for mood in ABI and be disseminated broadly via peer-reviewed journals, conference presentations and social media. ClinicalTrials.gov, NCT03874650 pre-results. Protocol version 2.1, March 5, 2019