INACTIVATION OF CA CONDUCTANCE DEPENDENT ON ENTRY OF CA IONS IN MOLLUSCAN NEURONS
INACTIVATION OF CA CONDUCTANCE DEPENDENT ON ENTRY OF CA IONS IN MOLLUSCAN NEURONS
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DOI：
10.1073/pnas.76.3.1497
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发表时间：
1979-01-01
影响因子：
11.1
通讯作者：
TILLOTSON, D
中科院分区：
文献类型：
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作者：
TILLOTSON, D
我们研究了在没有K电流的情况下，在离子载体制霉菌素的帮助下，在cs负载的细胞中，加州大鼠神经元Ca通道的失活。通过限制Ca进入的方法大大减少了失活。与钙的平衡电位相称的去极化导致最小的失活。细胞外钙被钡取代也减少了失活。钙通道的失活可能是钙进入程度的函数，而不是膜电位的函数，这与纯粹依赖电压的钠通道失活机制根本不同。
Inactivation of the Ca channel of Aplysia [californica] neurons was studied in the absence of K current in cells that were Cs-loaded with the aid of the ionophore nystatin. Inactivation was substantially decreased by methods that limited Ca entry. Depolarizations commensurate with the equilibrium potential of Ca resulted in minimal inactivation. Replacement of extracellular Ca by Ba also decreased inactivation. Inactivation of the Ca channel is probably a function of the extent of Ca entry rather than membrane potential, differing fundamentally from the purely voltage-dependent mechanism for Na inactivation.