Dissecting the brain's internal clock: How frontal-striatal circuitry keeps time and shifts attention
Dissecting the brain's internal clock: How frontal-striatal circuitry keeps time and shifts attention
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DOI：
10.1006/brcg.2001.1313
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发表时间：
2002-02-01
影响因子：
2.5
通讯作者：
Benson, AM
中科院分区：
文献类型：
--
作者：
Meck, WH;Benson, AM
生物体对事件的时间和时间顺序进行协调的能力，以及选择它们将要参与的内部和外部环境的特定方面的能力，对于生物体适应周围世界的能力至关重要。已经提出了许多心理学理论来描述生物体如何完成这种刺激选择，并表示离散的时间事件以及节奏产生。此外，大量研究表明，额纹状体回路的损伤似乎会损害生物体成功转移注意力和行为以适应不断变化的时间环境的能力。这表明，额纹状体回路参与了这种转变和处理时间间隔的能力。选择性的审查是在这篇文章中完成的，重点是具体的神经机制，可能涉及的时间间隔和设置转移。它的结论是，前额叶皮层，黑质pars丘脑，pedunculopontine核，和直接和间接的途径，从尾状核到丘脑可能提供的神经解剖学和神经生理学的基板，生物体的能力，将其注意力从一个时间的上下文转移到另一个。(C)2001年，爱思唯尔科学。
The ability of organisms to time and coordinate temporal sequences of events and to select particular aspects of their internal and external environments to which they will attend is vital to the organism's ability to adapt to the world around them. Numerous psychological theories have been proposed that describe how organisms might accomplish such stimulus selection and represent discrete temporal events as well as rhythm production. In addition, a large number of studies have demonstrated that damage to the frontostriatal circuitry appears to compromise the ability of organisms to successfully shift attention and behavior to adapt to changing temporal contexts. This suggests that frontostriatal circuitry is involved in the ability to make such shifts and to process temporal intervals. A selective review is accomplished in this article which focuses upon the specific neural mechanisms that may be, involved in interval timing and set shifting. It is concluded that prefrontal cortex, substantia nigra pars compacta, pedunculopontine nucleus, and the direct and indirect pathways from the caudate to the thalamus may provide the neuroanatomical and neurophysiological substrates that underlie the organism's ability to shift its attention from one temporal context to another. (C) 2001 Elsevier Science.