Environmental risk factors in neuromyelitis optica spectrum disorder: a case-control study
Environmental risk factors in neuromyelitis optica spectrum disorder: a case-control study
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DOI：
10.1007/s13760-018-0900-5
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发表时间：
2018-06-01
影响因子：
2.7
通讯作者：
Sahraian, Mohammad Ali
中科院分区：
文献类型：
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作者：
Eskandarieh, Sharareh;Nedjat, Saharnaz;Sahraian, Mohammad Ali
视神经脊髓炎谱系障碍 (NMOSD) 的危险因素尚不清楚。本研究的目的是确定 NMOSD 的环境风险因素。 2015 年至 2016 年，德黑兰对 100 名 NMOSD 患者进行了一项病例对照研究。通过随机数字拨号 (RDD) 选择性别匹配的健康对照 (n = 400)。 Logistic 回归用于通过 SPSS 估计 95% 置信区间 (Cl) 下未调整和调整的 OR（比值比）。与对照组人群相比，在 NMOSD 患者中，每周低乳制品摄入量的调整 OR 为（OR = 18.09；95% Cl 6.91,47.37），其次是低海鲜摄入量（OR = 13.91；95% Cl 6.13, 31.57）和低水果和蔬菜摄入量（OR = 6.23；95% Cl 3.07, 12.62）。患者中较低的剧烈体力活动（OR：16.11，95% Cl 7.03，36.91）增加了 NMOSD 的风险。既往头部外伤史被认为是 NMOSD 的风险（OR：8.39，95% Cl 4.97，14.16）。仅在女性中检测到 NMOSD 与故意堕胎之间的关联（OR：7.42，95% Cl 2.81，19.55）。这项研究表明，女性的饮食习惯、生活方式、头部外伤史和故意流产与后来的 NMOSD 诊断之间存在显着关联。
Neuromyelitis optica spectrum disorder (NMOSD) has unknown risk factors. The aim of this study was to identify the environmental risk factors for NMOSD. A case-control study was conducted in Tehran from 2015 to 2016 among 100 patients with NMOSD. Sex-matched healthy controls (n = 400) were selected through random digit dialing (RDD). Logistic regression was used to estimate unadjusted and adjusted ORs (odds ratio) at 95% confidence intervals (Cl) via SPSS. Compared with the control population, in NMOSD patients, the adjusted OR for low dairy consumption per week was (OR = 18.09; 95% Cl 6.91,47.37), following low sea food intake (OR = 13.91; 95% Cl 6.13, 31.57) and low fruit and vegetable consumption (OR = 6.23; 95% Cl 3.07, 12.62). The lower heavy physical activity (OR: 16.11, 95% Cl 7.03, 36.91) among patients had risen the risk of NMOSD. A past history of head trauma was considered a risk for NMOSD (OR: 8.39, 95% Cl 4.97, 14.16). The association between NMOSD and intentional abortion only among females (OR: 7.42, 95% Cl 2.81,19.55) was detected. This study indicates significant associations between dietary habits, life style, history of head trauma and intentional abortion in female and the later diagnosis of NMOSD.