Molecular Approaches to Understanding Transmission and Source Attribution in Nontyphoidal Salmonella and Their Application in Africa
Molecular Approaches to Understanding Transmission and Source Attribution in Nontyphoidal Salmonella and Their Application in Africa
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DOI：
10.1093/cid/civ727
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发表时间：
2015-11-01
影响因子：
11.8
通讯作者：
French, Nigel P.
中科院分区：
文献类型：
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作者：
Mather, Alison E.;Vaughan, Timothy G.;French, Nigel P.
非伤寒沙门氏菌（NTS）是世界各地腹泻的常见原因，但在许多非洲国家，它更常见于侵袭性细菌疾病。已经开发了各种来源归因模型，这些模型利用微生物亚型数据将人类NTS感染病例分配给不同的动物种群和动物源性食品。分子微生物分型方法的进展，特别是全基因组测序，为调查这些来源提供了更高分辨率的数据。在这篇综述中，我们提供了最新的沙门氏菌的来源归因模型，并研究应用全基因组测序数据结合进化建模调查推定的来源和传播途径的NTS，重点是在非洲的流行病学NTS。这是决定在哪里、什么以及如何最有效地应用控制策略的重要信息。
Nontyphoidal Salmonella (NTS) is a frequent cause of diarrhea around the world, yet in many African countries it is more commonly associated with invasive bacterial disease. Various source attribution models have been developed that utilize microbial subtyping data to assign cases of human NTS infection to different animal populations and foods of animal origin. Advances in molecular microbial subtyping approaches, in particular whole-genome sequencing, provide higher resolution data with which to investigate these sources. In this review, we provide updates on the source attribution models developed for Salmonella, and examine the application of whole-genome sequencing data combined with evolutionary modeling to investigate the putative sources and transmission pathways of NTS, with a focus on the epidemiology of NTS in Africa. This is essential information to decide where, what, and how control strategies might be applied most effectively.