Synovial Fluid: An Alternative Toxicologic Specimen?
Synovial Fluid: An Alternative Toxicologic Specimen?
复制标题
滑液：另一种毒理学样本？
DOI：
10.1097/paf.0000000000000097
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发表时间：
2014
影响因子：
1
通讯作者：
D. Molina
中科院分区：
文献类型：
--
作者：
Janine Deking;V. Hargrove;D. Molina
摘要血液是法医毒理学中最常用的标本，但并不总是可用的。在这些情况下，将寻找替代样本进行毒理学测试。目前的研究评估了滑液对死后可卡因和阿片类药物/阿片类药物检测的有用性。对104例病例进行了采样，其中98例接受检测，代表24例阴性对照，74例可卡因、苯甲酰芽子碱、吗啡、6-单乙酰吗啡、氢可酮和/或羟考酮阳性。滑膜表现出良好的相关性和可预测性相比，血液，虽然它是不敏感的6-单乙酰吗啡，无论是玻璃体或尿液。作者建议进一步研究以评估滑液在死后毒理学中的有用性，包括评估其对更多药物的利用，并开发进一步的测定方法以利用其潜力，即使是在有限的数量。
AbstractAlthough blood is the most commonly used specimen in forensic toxicology, it is not always available. In those cases, alternative samples are sought on which to perform toxicology testing. The current study assessed the usefulness of synovial fluid for postmortem cocaine and opiate/opioid testing. One hundred four cases were sampled, with 98 cases being tested representing 24 negative controls and 74 cases positive for cocaine, benzoylecgonine, morphine, 6-monoacetylmorphine, hydrocodone, and/or oxycodone. Synovium demonstrated excellent correlation and predictability when compared with blood, although it was not as sensitive for 6-monoacetylmorphine as either vitreous or urine. The authors recommend further study to assess the usefulness of synovial fluid in postmortem toxicology to include the evaluation of its utilize for more drugs and the development of further assays to use its potential even in limited quantities.