Cancer cell adhesion and metastasis: selectins, integrins, and the inhibitory potential of heparins.
Cancer cell adhesion and metastasis: selectins, integrins, and the inhibitory potential of heparins.
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DOI：
10.1155/2012/676731
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发表时间：
2012
影响因子：
--
通讯作者：
Borsig L
中科院分区：
文献类型：
--
作者：
Bendas G;Borsig L
细胞粘附分子在肿瘤的进展和转移中起重要作用。癌细胞与内皮细胞的细胞-细胞相互作用决定了转移扩散。此外，肿瘤细胞与血小板、白细胞和可溶性成分的直接相互作用显著促进癌细胞粘附、外渗和转移性病变的建立。临床证据表明，肝素，通常用于治疗血栓栓塞事件的癌症患者，是有益的，他们的生存。临床前研究证实，肝素具有抗转移活性，可导致各种动物模型中的转移减弱。肝素含有几种生物活性，可能影响转移级联反应中的几个步骤。在这里，我们专注于细胞粘附受体在转移级联的作用，并讨论肝素作为细胞粘附抑制剂的证据。虽然P-和L-选择素促进血行转移过程中的细胞接触被认为是肝素的潜在靶点，但我们认为肝素也可能干扰整合素活性，从而影响癌症进展。本文综述了近年来关于血管系统中肿瘤细胞相互作用的潜在机制以及肝素的抗肿瘤转移作用的研究进展。
Cell adhesion molecules play a significant role in cancer progression and metastasis. Cell-cell interactions of cancer cells with endothelium determine the metastatic spread. In addition, direct tumor cell interactions with platelets, leukocytes, and soluble components significantly contribute to cancer cell adhesion, extravasation, and the establishment of metastatic lesions. Clinical evidence indicates that heparin, commonly used for treatment of thromboembolic events in cancer patients, is beneficial for their survival. Preclinical studies confirm that heparin possesses antimetastatic activities that lead to attenuation of metastasis in various animal models. Heparin contains several biological activities that may affect several steps in metastatic cascade. Here we focus on the role of cellular adhesion receptors in the metastatic cascade and discuss evidence for heparin as an inhibitor of cell adhesion. While P- and L-selectin facilitation of cellular contacts during hematogenous metastasis is being accepted as a potential target of heparin, here we propose that heparin may also interfere with integrin activity and thereby affect cancer progression. This review summarizes recent findings about potential mechanisms of tumor cell interactions in the vasculature and antimetastatic activities of heparin.