Alteration of SSAO interactome reveals weakened cell adhesion and motor function of adipocytes in T2D
Alteration of SSAO interactome reveals weakened cell adhesion and motor function of adipocytes in T2D
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SSAO 相互作用组的改变揭示了 T2D 中脂肪细胞的细胞粘附和运动功能减弱
DOI：
10.1093/abbs/gmx069
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发表时间：
2017
影响因子：
3.7
通讯作者：
Deng Yulin
中科院分区：
文献类型：
--
作者：
Ke Ming;Zhang Yongqian;Deng Yulin
图1.免疫共沉淀样品的SDS-PAGE和Western印迹分析以及T2D中潜在的SSAO相互作用伙伴的功能注释聚类分析(A)抗SSAO抗体和正常免疫沉淀物在SDS-PAGE中显示出明显的差异，Western印迹结果表明SSAO在抗SSAO抗体免疫沉淀物中显著富含。(B)在MF的运动活性、CC的黏附、BP的钙离子转运以及KEGG途径中的碳代谢、丙酮酸代谢、胰岛素分泌和胆碱能突触显著丰富。(C)在T2D中，改变的和未改变的/未知的蛋白质数量显著丰富。分子功能；CC，细胞成分；BP，生物过程。
Figure 1. SDS-PAGE and western blot analysis of co-immunoprecipitation samples and functional annotation clustering analysis of potential SSAO-interacting partners in T2D (A) Anti-SSAO antibody and normal IgG immunoprecipitates showed distinct differences in SDS-PAGE, and the western blot result showed that SSAO was significantly enriched in the anti-SSAO antibody immunoprecipitate.(B) Clusters of motor activity in MF, adhesion in CC, calcium ion transport in BP, and carbon metabolism, pyruvate metabolism, insulin secretion, and cholinergic synapse in KEGG pathway were found to be significantly enriched.(C) The number of changed and unchanged/unknown proteins in T2D with significantly enriched clusters. MF, molecular function; CC, cellular component; BP, biological process.