CORTICAL GABA-B AND GABA-A RECEPTORS IN ALZHEIMERS-DISEASE - A QUANTITATIVE AUTORADIOGRAPHIC STUDY
CORTICAL GABA-B AND GABA-A RECEPTORS IN ALZHEIMERS-DISEASE - A QUANTITATIVE AUTORADIOGRAPHIC STUDY
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DOI：
10.1212/wnl.37.9.1454
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发表时间：
1987-09-01
期刊：
影响因子：
9.9
通讯作者：
YOUNG, AB
中科院分区：
文献类型：
--
作者：
CHU, DCM;PENNEY, JB;YOUNG, AB
通过对死于阿尔茨海默氏型痴呆 (DAT) 的人和年龄匹配的正常对照者的额上回中的 3H-GABA 结合进行定量放射自显影来评估 GABAB 和 GABAA 结合位点。 Scatchard 分析和竞争研究揭示，与对照组相比，DAT 额叶皮层 II、III 和 V 层中 GABAB 和 GABAA 受体的受体密度 (Bmax) 分别减少 48% 至 68% 和 25%。未发现 GABAA 或 GABAB 受体的亲和力 (KD) 存在显着差异。我们的数据可能反映 DAT 新皮质的多系统病理学参与。
GABAB and GABAA binding sites were evaluated by quantitative autoradiography of 3H-GABA binding in superior frontal gyrus of persons who died with dementia of the Alzheimer''s type (DAT) and of age-matched normal controls. Scatchard analysis and competition studies disclosed 48 to 68% and 25% decrements in receptor density (Bmax) for GABAB and GABAA receptors, respectively, in layers II, III, and V of DAT frontal cortex as compared with controls. No significant difference in affinity (KD) for either GABAA or GABAB receptors was found. Our data may reflect multisystem pathologic involvement in DAT neocortex.