A human melanoma line heterogeneous with respect to metastatic capacity in athymic nude mice.
A human melanoma line heterogeneous with respect to metastatic capacity in athymic nude mice.
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DOI：
10.1093/jnci/72.4.913
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发表时间：
1984-04
期刊：
影响因子：
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通讯作者：
J. Kozlowski;J. Kozlowski;I. Hart;I. Fidler;N. Hanna
中科院分区：
文献类型：
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作者：
J. Kozlowski;J. Kozlowski;I. Hart;I. Fidler;N. Hanna
研究了人A375黑色素瘤细胞系在年轻BALB/c裸鼠中产生实验性和自发性的能力。通过在半固体琼脂中分离获得的克隆系在静脉注射后形成肺肿瘤结节的能力方面与亲本肿瘤系显著不同（检查的4/10个克隆系，P小于或等于0.005）。从这种肺肿瘤结节建立的细胞系在静脉注射和皮下注射后比亲本细胞系更具转移性。这些结果表明，在这些研究中使用的人黑色素瘤细胞系含有不同的转移潜力的细胞，并表明，在裸鼠中的转移的结果从转移性亚群的优先选择。
The ability of the human A375 melanoma cell line to produce experimental and spontaneous in young BALB/c nude mice was examined. Cloned lines, obtained by isolation in semisolid agar, differed significantly (4/10 cloned lines examined, P less than or equal to .005) from the parent tumor line with regard to their ability to form lung tumor nodules subsequent to iv injection. Lines established from such lung tumor nodules were more metastatic than the parent line following both iv and sc injection. These results show that the human melanoma cell line used in these studies contained cells with diverse metastatic potential and suggest that metastasis in the nude mouse results from the preferential selection of metastatic subpopulations.