Resolving Salmonella infection reveals dynamic and persisting changes in murine bone marrow progenitor cell phenotype and function.
Resolving Salmonella infection reveals dynamic and persisting changes in murine bone marrow progenitor cell phenotype and function.
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DOI：
10.1002/eji.201344350
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发表时间：
2014-08
影响因子：
5.4
通讯作者：
Cunningham, Adam F.
中科院分区：
文献类型：
--
作者：
Ross, Ewan A.;Flores-Langarica, Adriana;Bobat, Saeeda;Coughlan, Ruth E.;Marshall, Jennifer L.;Hitchcock, Jessica R.;Cook, Charlotte N.;Carvalho-Gaspar, Manuela M.;Mitchell, Andrea M.;Clarke, Mary;Garcia, Paloma;Cobbold, Mark;Mitchell, Tim J.;Henderson, Ian R.;Jones, Nick D.;Anderson, Graham;Buckley, Christopher D.;Cunningham, Adam F.
从BM前体产生免疫细胞是一个仔细调节的过程。这对于限制肿瘤发生和自身免疫的可能性，同时防止感染是至关重要的。感染是如何调节这一点尚不清楚。沙门氏菌可定植于全身部位，包括BM和脾脏。这种消退性感染对BM祖细胞具有多种IFN-γ介导的急性和慢性作用，并且在感染的第一周期间，IFN-γ由骨髓、NK、NKT、CD 4 + T细胞和一些谱系阴性细胞产生。感染后，BM祖细胞的表型迅速但可逆地改变，Sca-1hi祖细胞的峰值增加约30倍，Sca-1 lo/int亚群相应丢失。最引人注目的是，供体Sca-1hi细胞重建辐射宿主的能力降低;供体小鼠暴露于感染的时间越长，Sca-1hic-kitint细胞产生B1 a样细胞的潜力就越大。因此，沙门氏菌可以对与细菌持久性不直接相关的BM祖细胞功能具有长期影响。这些结果反映了在衰老过程中观察到的白细胞生成的变化，并表明BM功能可以通过终身定期暴露于感染来调节。更好地了解这一过程可以提供新的治疗机会，以调节BM功能和促进健康老龄化。
The generation of immune cells from BM precursors is a carefully regulated process. This is essential to limit the potential for oncogenesis and autoimmunity yet protect against infection. How infection modulates this is unclear. Salmonella can colonize systemic sites including the BM and spleen. This resolving infection has multiple IFN-γ-mediated acute and chronic effects on BM progenitors, and during the first week of infection IFN-γ is produced by myeloid, NK, NKT, CD4+ T cells, and some lineage-negative cells. After infection, the phenotype of BM progenitors rapidly but reversibly alters, with a peak ∼30-fold increase in Sca-1hi progenitors and a corresponding loss of Sca-1lo/int subsets. Most strikingly, the capacity of donor Sca-1hi cells to reconstitute an irradiated host is reduced; the longer donor mice are exposed to infection, and Sca-1hic-kitint cells have an increased potential to generate B1a-like cells. Thus, Salmonella can have a prolonged influence on BM progenitor functionality not directly related to bacterial persistence. These results reflect changes observed in leucopoiesis during aging and suggest that BM functionality can be modulated by life-long, periodic exposure to infection. Better understanding of this process could offer novel therapeutic opportunities to modulate BM functionality and promote healthy aging.
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DOI：
10.4049/jimmunol.1001893
发表时间：
2011-01-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
MacNamara KC;Oduro K;Martin O;Jones DD;McLaughlin M;Choi K;Borjesson DL;Winslow GM
通讯作者：
Winslow GM
影响因子：
3.7
作者：
MacNamara KC;Jones M;Martin O;Winslow GM
通讯作者：
Winslow GM
影响因子：
64.5
作者：
Kiel, MJ;Yilmaz, ÖH;Morrison, SJ
通讯作者：
Morrison, SJ
影响因子：
7.8
作者：
Kuranda, Klaudia;Vargaftig, Jacques;Goodhardt, Michele
通讯作者：
Goodhardt, Michele
影响因子：
4.4
作者：
Gaspal, Fabrina;Bekiaris, Vasileios;Cunningham, Adam F.
通讯作者：
Cunningham, Adam F.