Food dependence in rats selectively bred for low versus high saccharin intake. Implications for "food addiction"
Food dependence in rats selectively bred for low versus high saccharin intake. Implications for "food addiction"
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DOI：
10.1016/j.appet.2011.06.002
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发表时间：
2011-10-01
期刊：
影响因子：
5.4
通讯作者：
Dess, Nancy K.
中科院分区：
文献类型：
--
作者：
Yakovenko, Veronica;Speidel, Elizabeth R.;Dess, Nancy K.
“食物成瘾”的概念意味着药物依赖和食物依赖的倾向应该是相互关联的。后者在低（LoS）和高（HiS）糖精消耗大鼠中进行了研究，这些大鼠在药物自我给药（HiS > LOS）和戒断（LoS > HiS）方面存在差异。在第一个1-2小时的含糖食物摄入量高，在HiS比LoS大鼠。糖的摄入量预测惊吓期间禁欲只有LoS大鼠。这些结果可能提示HiS大鼠存在暴食倾向，LoS大鼠存在戒断倾向。然而，摄入量的增加和躯体戒断没有不同的线。进一步研究选择性饲养的大鼠，注意定义和措施，是必要的。(C)2011爱思唯尔有限公司保留所有权利。
The "food addiction" concept implies that proneness to drug dependence and to food dependence should covary. The latter was studied in low- (LoS) and high- (HiS) saccharin-consuming rats, who differ in drug self-administration (HiS > LOS) and withdrawal (LoS > HiS). Sugary food intake in the first 1-2 h was higher in HiS than LoS rats. Sugar intake predicted startle during abstinence only among LoS rats. These results may suggest bingeing-proneness in HiS rats and withdrawal-proneness among LoS rats. However, intake escalation and somatic withdrawal did not differ between lines. Further study with selectively bred rats, with attention to definitions and measures, is warranted. (C) 2011 Elsevier Ltd. All rights reserved.