Immunocytochemical localization of human papilloma virus and cytomorphologic correlation in smears and biopsies of cervical flat condylomata

Immunocytochemical localization of human papilloma virus and cytomorphologic correlation in smears and biopsies of cervical flat condylomata
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宫颈扁平湿疣涂片和活检中人乳头瘤病毒的免疫细胞化学定位和细胞形态学相关性

DOI:
10.1002/dc.2840020410
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发表时间:
1986
影响因子:
1.3
通讯作者:
M. Hutchinson
M. Hutchinson
中科院分区:
医学4区
文献类型:
--
作者:
H. Deligeorgi‐Politi;K. K. Mui;K. Trotta;H. Safaii;S. H. An;H. Wolfe;M. Hutchinson

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介绍了免疫过氧化物酶染色技术所证明的与人乳头瘤病毒抗原(Ag)表达相关的宫颈活检和涂片的细胞形态学特征。人乳头瘤病毒 Ag 的免疫过氧化物酶染色的细胞学和活检结果具有良好的一致性。低度病变(宫颈上皮内瘤变,0 级和 I 级)的细胞形态学评分显示,Ag+ 活检标本中非典型有丝分裂、大核挖空细胞、浅表细胞角质透明颗粒和多核现象更为常见。 Ag 活检标本中的慢性炎症更为明显(P < 0.05)。 Ag+细胞学标本中角化不全更为常见。挖空细胞增多并不是这两种制剂中 Ag 表达的可靠指标。通过免疫过氧化物酶技术进行人乳头瘤病毒 (HPV) Ag 检测似乎是筛查低度宫颈异型性的有用辅助手段。 Diagn Cytopathol 1986;2:320-325。
The cytomorphologic features in cervical biopsies and smears associated with human papilloma virus antigen (Ag) expression as demonstrated by immunoperoxidase staining techniques are presented. There was good concordance between cytology and biopsy results with respect to immunoperoxidase staining for human papilloma virus Ag. Cytomorphologic scoring of low‐grade lesions (cervical intraepithelial neoplasias, grades 0 and I) showed atypical mitoses, macronucleated koilocytes, superficial cell keratohyaline granules, and multinucleation to be more frequent in Ag+ biopsy specimens. Chronic inflammation was more evident in Ag‐ biopsy specimens (P < 0.05). Parakeratosis was more frequent in Ag+ cytologic specimens. Koilocytosis was not a reliable indicator of Ag expression in either preparation. Human papilloma virus (HPV) Ag testing by immunoperoxidase techniques appears to be a useful adjunct for screening low‐grade atypias of the cervix. Diagn Cytopathol 1986;2:320‐325.
人乳头瘤病毒感染和宫颈上皮内瘤变:组织病理学和 DNA 含量。
DOI: --
发表时间: 1984
影响因子: 7.2
作者:
Fujii,T;Crum,CP;Winkler,B;Fu,YS;Richart,RM
通讯作者: Richart,RM
女性生殖道尖锐湿疣组织中乳头瘤病毒抗原的免疫学鉴定。
DOI: --
发表时间: 1980
影响因子: 7.2
作者:
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DOI: --
发表时间: 1981
期刊: Journal of the National Cancer Institute
影响因子: --
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通讯作者: Meisels,A