EVALUATION OF THE MAXIMUM-LIKELIHOOD ESTIMATE OF THE EVOLUTIONARY TREE TOPOLOGIES FROM DNA-SEQUENCE DATA, AND THE BRANCHING ORDER IN HOMINOIDEA
EVALUATION OF THE MAXIMUM-LIKELIHOOD ESTIMATE OF THE EVOLUTIONARY TREE TOPOLOGIES FROM DNA-SEQUENCE DATA, AND THE BRANCHING ORDER IN HOMINOIDEA
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DOI：
10.1007/bf02100115
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发表时间：
1989-01-01
影响因子：
3.9
通讯作者：
HASEGAWA, M
中科院分区：
文献类型：
--
作者：
KISHINO, H;HASEGAWA, M
从DNA序列数据推断进化树的最大似然方法是由Felsenstein（1981）开发的。在评估最大似然树在多大程度上是真正的树的一个显着更好的表示，重要的是要估计不同的树拓扑的对数似然之间的差异的方差。Bootstrap resource可以用于此目的（Hasegawa et al. 1988; Hasegawa and Kishino 1989），但它会带来很大的计算负担。为了克服这一困难，我们提出了一种新的方法来估计方差，并将该方法应用于灵长类DNA序列数据，以估计人总科的最大似然分支顺序。结果表明，虽然猩猩是令人信服的人类和非洲猿分支的外群，人类，黑猩猩和大猩猩之间的分支顺序不能确定有信心的DNA序列数据时，目前可用的进化速率常数不假设。
A maximum likelihood method for inferring evolutionary trees from DNA sequence data was developed by Felsenstein (1981). In evaluating the extent to which the maximum likelihood tree is a significantly better representation of the true tree, it is important to estimate the variance of the difference between log likelihood of different tree topologies. Bootstrap resampling can be used for this purpose (Hasegawa et al. 1988; Hasegawa and Kishino 1989), but it imposes a great computation burden. To overcome this difficulty, we developed a new method for estimating the variance by expressing it explicitly.The method was applied to DNA sequence data from primates in order to evaluate the maximum likelihood branching order among Hominoidea. It was shown that, although the orangutan is convincingly placed as an outgroup of a human and African apes clade, the branching order among human, chimpanzee, and gorilla cannot be determined confidently from the DNA sequence data presently available when the evolutionary rate constancy is not assumed.