Cucurbitacin I inhibits cell migration and invasion and enhances chemosensitivity in colon cancer
Cucurbitacin I inhibits cell migration and invasion and enhances chemosensitivity in colon cancer
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葫芦素 I 抑制结肠癌细胞迁移和侵袭并增强化疗敏感性
DOI：
10.3892/or.2015.3749
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发表时间：
2015-04-01
期刊：
影响因子：
4.2
通讯作者：
Wang, Chaojie
中科院分区：
文献类型：
--
作者：
Song, Junmin;Liu, Hongxiang;Wang, Chaojie
结直肠癌是世界上第三大常见的癌症类型。手术切除由于转移而不能完全消除肿瘤。存在对新的化疗工具的需求。在本研究中，我们研究了从葫芦科植物中提取的天然成分葫芦素I在结肠癌细胞株COLO 205中的化学预防潜力。我们假设葫芦素I可以阻止结肠癌细胞的迁移和侵袭，并使结肠癌细胞对化疗敏感。我们的数据表明，COLO 205细胞暴露于葫芦素I显着降低细胞活力。此外，我们的数据首次证明，在COLO 205细胞中，葫芦素I可以抑制细胞的迁移和侵袭，并具有对结肠癌的化学增敏活性。葫芦素I的抗癌活性是通过下调p-STAT 3和MMP-9的表达来实现的。总的来说，我们的研究结果表明，葫芦素I可能是一个有效的辅助化疗剂，结肠癌的抗迁移，抗侵袭和化疗增敏活动。
Colorectal cancers are the third most common types of cancers worldwide. Surgical resection is unable to eliminate tumors completely due to metastasis. A demand for new chemotherapeutic tools exists. In the present study, we examined the chemopreventive potential of cucurbitacin I, a natural component extracted from plants of the Cucurbitaceae family, in the colon cancer cell line COLO205. We hypothesized that cucurbitacin I would prevent colon cancer cell migration and invasion, and sensitize colon cancer cells to chemotherapy. Our data demonstrated that exposure of the COLO205 cells to cucurbitacin I significantly decreased cell viability. Furthermore our data demonstrated for the first time that in the COLO205 cells, cucurbitacin I could suppress the cell migration and invasion, and harbor chemosensitization activity against colon cancer. The anticancer activity of cucurbitacin I was accomplished by downregulating p-STAT3 and MMP-9 expression. Collectively, our results suggest that cucurbitacin I may be a potent adjuvant chemotherapeutic agent for colon cancer with anti-migration, anti-invasion and chemosensitizing activities.