Induction of protective immunity to monoclonal-antibody-defined Plasmodium falciparum antigens requires strong adjuvant in Aotus monkeys
Induction of protective immunity to monoclonal-antibody-defined Plasmodium falciparum antigens requires strong adjuvant in Aotus monkeys
复制标题
在 Aotus 猴中诱导针对单克隆抗体定义的恶性疟原虫抗原的保护性免疫需要强佐剂
DOI：
10.1128/iai.52.1.314-318.1986
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发表时间：
1986
影响因子：
3.1
通讯作者：
G. Hui
中科院分区：
文献类型：
--
作者：
W. A. Siddiqui;L. Tam;S. Kan;K. Kramer;S. Case;K. Palmer;K. Yamaga;G. Hui
制备了抗恶性疟原虫裂殖子表面衣壳和杆状病毒抗原的单抗。亲和纯化的多肽与给予三次弗氏完全佐剂的组合可完全保护天青Aotus lemurous azure(Kartype VI)猴免受同源攻击；然而，即使诱导出类似的高抗体滴度，同样的多肽与壁壁基二肽衍生物[MDP-Lys(L18)]免疫并不能保护第二只Aotus猴。
Monoclonal antibodies to the major Plasmodium falciparum merozoite surface coat and rhoptry antigens were produced. A combination of the affinity-purified polypeptides with Freund complete adjuvant which was given three times completely protected an Aotus lemurinus azure (karotype VI) monkey against homologous challenge; however, immunization with the same polypeptides with a muramyl dipeptide derivative [MDP-Lys(L18)] did not protect a second Aotus monkey, even though comparable high antibody titers were induced.