The chemotactic cytokine eotaxin acts as a granulocyte-macrophage colony-stimulating factor during lung inflammation
The chemotactic cytokine eotaxin acts as a granulocyte-macrophage colony-stimulating factor during lung inflammation
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DOI：
10.1182/blood.v91.6.1909.1909_1909_1916
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发表时间：
1998-03-15
期刊：
影响因子：
20.3
通讯作者：
Gutierrez-Ramos, JC
中科院分区：
文献类型：
--
作者：
Peled, A;Gonzalo, JA;Gutierrez-Ramos, JC
在炎症过程中，炎症组织向骨髓(BM)发出信号，以尚不清楚的方式产生更成熟的白细胞。我们在此报道，在肺变态反应性炎症的发展过程中，对趋化细胞因子嗜酸性粒细胞趋化因子的中和抗体的应用阻止了骨髓中产生的髓系祖细胞数量的增加，从而减少了骨髓中成熟髓系细胞的产量。相反，体内注射嗜酸粒细胞趋化因子增加了骨髓中存在的髓系祖细胞的数量。此外，我们发现，在体外，嗜酸性粒细胞趋化因子是一种粒细胞和巨噬细胞的集落刺激因子。嗜酸性粒细胞趋化因子与干细胞因子协同作用，但不与白介素3或粒细胞-巨噬细胞集落刺激因子协同作用，并被百日咳毒素抑制。我们还报道了嗜酸性粒细胞趋化因子受体CCR-3是由造血祖细胞表达的。因此，在炎症过程中，嗜酸性粒细胞趋化因子以旁分泌的方式将BM HP的分化向髓系转移。(C)1998年由美国血液病学会主办。
During inflammatory processes, inflamed tissues signal the bone marrow (BM) to produce more mature leukocytes in ways that are not yet understood. We report here that, during the development of lung allergic inflammation, the administration of neutralizing antibodies to the chemotactic cytokine, Eotaxin, prevented the increase in the number of myeloid progenitors produced in the BM, therefore reducing the output of mature myeloid cells from BM. Conversely, the in vivo administration of Eotaxin increased the number of myeloid progenitors present in the BM. Furthermore, we found that, in vitro, Eotaxin is a colony-stimulating factor for granulocytes and macrophages. Eotaxin activity synergized with stem cell factor but not with interleukin-3 or granulocyte-macrophage colony-stimulating factor and was inhibited by pertussis toxin. We report also that CCR-3, the receptor for Eotaxin, was expressed by hematopoietic progenitors (HP). Thus, during inflammation, Eotaxin acts in a paracrine way to shift the differentiation of BM HP towards the myeloid lineage. (C) 1998 by The American Society of Hematology.