PROGESTERONE THERAPY IN WOMEN WITH COMPLEX PARTIAL AND SECONDARY GENERALIZED SEIZURES
PROGESTERONE THERAPY IN WOMEN WITH COMPLEX PARTIAL AND SECONDARY GENERALIZED SEIZURES
复制标题
DOI：
10.1212/wnl.45.9.1660
复制
发表时间：
1995-09-01
期刊：
影响因子：
9.9
通讯作者：
HERZOG, AG
中科院分区：
文献类型：
--
作者：
HERZOG, AG
这项开放性试验评估了连续性孕酮治疗对25名女性复杂部分性（CPS）和继发性全身性运动（SGMS）癫痫发作的月经加重的癫痫发作频率的影响。25名女性中有23名对Progesterone耐受良好，2名患者出现易逆转的剂量相关性虚弱和情绪抑郁副作用。与治疗前3个月相比，18名女性（72%）在3个月的治疗期间癫痫发作频率下降（p < 0.01）。平均每日CPS频率下降54%（p < 0.01），SGMS下降58%（p < 0.02）。
This open trial assessed the effects of adjunctive progesterone therapy on seizure frequency in 25 women with catamenial exacerbation of complex partial (CPS) and secondary generalized motor (SGMS) seizures. Progesterone was well tolerated by 23 of the 25 women and had readily reversible dose-related side effects of asthenia and emotional depression in two. Eighteen women (72%) experienced a decline in seizure frequency during a 3-month treatment period compared with the 3 months prior to therapy (p < 0.01). Average daily CPS frequency declined by 54% (p < 0.01), SGMS by 58% (p < 0.02).