Membrane protein trafficking in Drosophila photoreceptor cells.
Membrane protein trafficking in Drosophila photoreceptor cells.
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DOI：
10.1016/j.ejcb.2016.11.002
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发表时间：
2017-08
影响因子：
6.6
通讯作者：
Krystina Schopf;A. Huber
中科院分区：
文献类型：
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作者：
Krystina Schopf;A. Huber
膜蛋白运输发生在神经元的整个生命周期中，包括最初的蛋白质合成和顺行运输到质膜，以及质膜蛋白的内化、降解和再循环。蛋白质运输的缺陷可能导致神经元变性，并成为色素性视网膜炎等致盲性疾病以及其他神经元疾病的基础。果蝇感光细胞已成为识别神经元膜蛋白质运输所涉及的成分和机制的模型系统。在这里，我们总结了目前关于三种果蝇光转导蛋白、视觉色素视紫红质和两个光激活离子通道 TRP（瞬时受体电位）和 TRPL（TRP 样）运输的知识。尽管视紫红质和 TRP 具有一些共同的要求，但这些蛋白质运输的细节差异很大，表明这些光感受器蛋白质存在多种运输途径。
Membrane protein trafficking occurs throughout the lifetime of neurons and includes the initial protein synthesis and anterograde transport to the plasma membrane as well as internalization, degradation, and recycling of plasma membrane proteins. Defects in protein trafficking can result in neuronal degeneration and underlie blinding diseases such as retinitis pigmentosa as well as other neuronal disorders.Drosophilaphotoreceptor cells have emerged as a model system for identifying the components and mechanisms involved in membrane protein trafficking in neurons. Here we summarize the current knowledge about trafficking of threeDrosophilaphototransduction proteins, the visual pigment rhodopsin and the two light-activated ion channels TRP (transient receptor potential) and TRPL (TRP-like). Despite some common requirements shared by rhodopsin and TRP, details in the trafficking of these proteins differ considerably, suggesting the existence of several trafficking pathways for these photoreceptor proteins.