Microstimulation of sensory cortex engages natural sensory representations.
Microstimulation of sensory cortex engages natural sensory representations.
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感觉皮层的微刺激涉及自然的感觉表征。
DOI：
10.1016/j.cub.2023.03.085
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Peron,Simon
中科院分区：
文献类型：
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作者：
Pancholi,Ravi;Sun-Yan,Andrew;Peron,Simon
皮层活动模式占据了可能的网络状态的一小部分。如果这是由于内在的网络特性，感觉皮层的微刺激应该引起类似于在自然感觉输入期间观察到的活动模式。在这里，我们使用光学微刺激的病毒转染层2/3锥体神经元在小鼠初级触须体感皮层比较人工诱发的活动与自然活动引起的胡须触摸和运动（“搅拌”）。我们发现，光刺激参与触摸-但不是搅拌反应神经元比预期的更多的机会。对光刺激和触摸或单独触摸作出反应的神经元比纯粹的光响应神经元表现出更高的自发成对相关性。暴露于几天的同时触摸和光遗传学刺激提高触摸和光响应神经元之间的重叠和自发活动的相关性。因此，我们发现，皮质微刺激从事现有的皮质表示和自然和人工刺激的重复共同介绍增强了这种效果。
Cortical activity patterns occupy a small subset of possible network states. If this is due to intrinsic network properties, microstimulation of sensory cortex should evoke activity patterns resembling those observed during natural sensory input. Here, we use optical microstimulation of virally transfected layer 2/3 pyramidal neurons in the mouse primary vibrissal somatosensory cortex to compare artificially evoked activity with natural activity evoked by whisker touch and movement ("whisking"). We find that photostimulation engages touch- but not whisking-responsive neurons more than expected by chance. Neurons that respond to photostimulation and touch or to touch alone exhibit higher spontaneous pairwise correlations than purely photoresponsive neurons. Exposure to several days of simultaneous touch and optogenetic stimulation raises both overlap and spontaneous activity correlations among touch and photoresponsive neurons. We thus find that cortical microstimulation engages existing cortical representations and that repeated co-presentation of natural and artificial stimulation enhances this effect.