Structure-function studies of DNA polymerase lambda
Structure-function studies of DNA polymerase lambda
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DOI：
10.1016/j.dnarep.2005.09.001
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发表时间：
2005-12-08
期刊：
影响因子：
3.8
通讯作者：
Kunkel, TA
中科院分区：
文献类型：
--
作者：
Garcia-Diaz, M;Bebenek, K;Kunkel, TA
DNA聚合酶lambda是X聚合酶家族中的一员，参与DNA双链断裂的非同源末端连接和DNA损伤的碱基切除修复。为了更好地了解DNA聚合酶lambda在这些修复途径中的作用，我们对其结构和生化性质进行了综述，重点介绍了它的缺口-耕作聚合活性、DRP裂解酶活性和它特殊的DNA合成(不)保真度。爱思唯尔出版公司(Elsevier B.V.)
DNA polymerase lambda is a member of the X family of polymerases that is implicated in non-homologous end-joining of double-strand breaks in DNA and in base excision repair of DNA damage. To better understand the roles of DNA polymerase lambda in these repair pathways, here we review its structure and biochemical properties, with emphasis on its gap-tilling polymerization activity, its dRP lyase activity and its unusual DNA synthetic (in)fidelity. Published by Elsevier B.V.