Gold Nanorod-Photosensitizer Complex for Near-Infrared Fluorescence Imaging and Photodynamic/Photothermal Therapy In Vivo
Gold Nanorod-Photosensitizer Complex for Near-Infrared Fluorescence Imaging and Photodynamic/Photothermal Therapy In Vivo
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DOI：
10.1021/nn102722z
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发表时间：
2011-02-01
期刊：
影响因子：
17.1
通讯作者：
Choi, Yongdoo
中科院分区：
文献类型：
--
作者：
Jang, Boseung;Park, Jin-Young;Choi, Yongdoo
研究了一种用于无创近红外荧光成像和肿瘤治疗的金纳米棒光敏剂复合物。结果表明：(a) AIPcS4与GNRs形成配合物后，其荧光发射和单线态氧生成被猝灭；(b) GNR-AIPcS(4)处理的细胞比自由AIPcS(4)处理的细胞胞内摄取多4倍，体外光毒性更好；(c)静脉注射GNR-AIPcS(4)复合物后，早在注射后1 h的近红外荧光图像上就能清楚地识别出肿瘤部位。肿瘤/背景比随着时间的推移而增加，24 h时为33；单独光动力治疗（PDT）可使肿瘤生长减少79%，双光热治疗（PTT）和PDT可使肿瘤生长减少95%。这种新型多功能纳米药物可用于各种癌症的近红外荧光成像和PTT/PDT。
A gold nanorod (GNR)-photosensitizer complex was developed for noninvasive near-infrared fluorescence imaging and cancer therapy. We showed that (a) fluorescence emission and singlet oxygen generation by AIPcS4 were quenched after complex formation with GNRs; (b) 4-fold greater intracellular uptake and better in vitro phototoxicity were observed in GNR-AIPcS(4)-treated cells than in free AIPcS(4)-treated cells; and (c) after intravenous injection of the GNR-AIPcS(4) complex, tumor sites were clearly identified on near-Infrared fluorescence images as early as 1 h after injection. The tumor-to-background ratio increased over time and was 33 at 24 h; tumor growth reduced by 79% with photodynamic therapy (PDT) alone and by 95% with dual photothermal therapy (PTT) and PDT. This novel multifunctional nanomedicine may be useful for near-infrared fluorescence imaging and PTT/PDT in various cancers.