Serotonin Transporter Gene Promoter Polymorphism and Alexithymia
Serotonin Transporter Gene Promoter Polymorphism and Alexithymia
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DOI：
10.1159/000329554
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发表时间：
2012-01-01
影响因子：
3.2
通讯作者：
Fukudo, Shin
中科院分区：
文献类型：
--
作者：
Kano, Michiko;Mizuno, Tomoko;Fukudo, Shin
背景：近年来的神经生物学研究表明，述情障碍可能是由于与情绪处理相关的脑功能改变所致。血清素（5-羟色胺，5-HT）已被证明可以调节与心理加工相关的中枢神经系统发育。我们研究了5-HT转运体连接启动子区（5-HTTLPR）多态性与述情障碍相关的可能性。方法：本研究包括304名日本健康志愿者（男性148名，女性156名）。根据基因型（L/L、L/S、S/S）和20项多伦多述情障碍量表（TAS-20）、状态-特质焦虑量表（STAI）和抑郁自评量表（SDS）的结果对受试者进行分类。结果如下：与L/S或S/S基因型受试者相比，L/L基因型受试者的TAS-20评分显著更高，并且难以识别感觉（DIE）子量表的评分也显著更高（p < 0.05）。5-HTTLPR基因型与DIF评分的相关性存在性别差异。女性受试者中，L/L基因型的DIF评分显著高于L/S或S/S基因型（p
Background: Recent neurobiological studies have reported that alexithymia may result from altered brain function related to emotional processing. Serotonin (5-hydroxytryptamine, 5-HT) has been shown to regulate central nervous system development associated with psychological processing. We investigated the possibility that polymorphism of the 5-HT transporter-linked promoter region (5-HTTLPR) is associated with alexithymia. Methods: This study included 304 healthy Japanese volunteers (148 males, 156 females). The subjects were categorized according to genotype (L/L, L/S, S/S) and results of the 20-item Toronto Alexithymia Scale (TAS-20), State-Trait Anxiety Inventory (STAI) and Self-Rating Depression Scale (SDS). Results: Subjects with the L/L genotype showed significantly higher TAS-20 scores, as well as significantly higher scores on the difficulty identifying feeling (DIE) subscale, than those with the L/S or S/S genotype (p < 0.05). There was a gender difference in the association between 5-HTTLPR genotype and DIF score. Female subjects with the L/L genotype showed significantly higher DIF scores than those with the L/S or S/S genotype (p